Review: Adding long-acting beta2-agonists to inhaled corticosteroids reduces asthma exacerbations more than adding antileukotrienes

Smith, Brian
July 2005
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p46
Academic Journal
This article presents information on a study related to long-acting beta2-agonists (LABAs) versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma. Randomized controlled trials comparing LABAs or leukotriene-receptor antagonists added to inhaled corticosteroids in patients with recurrent or persistent asthma. Patients were required to be on a stable dose of inhaled corticosteroid during a treatment period 28 days. The quality of the individual studies was assessed with the Jadad scale. The results of the study showed that the asthma exacerbations requiring systemic corticosteroids. Secondary outcomes included asthma control measures, adverse effects, and withdrawals.


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