Review: Bisphosphonates are modestly better than placebo for relieving painful bone metastases

Stockler, Martin
July 2005
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p31
Academic Journal
This article presents information on a study related to utilization of bisphosphonate agents for the management of pain secondary to bone metastases. Randomized controlled trials (RCTs) that included patients who had bone metastases with or without pain at enrollment, measured pain as an outcome, allowed antineoplastic therapy or rescue pain medications, and compared bisphosphonates with a control intervention. Using a random-effects model, meta-analysis of 5 RCTs showed greater pain relief with bisphosphonates than with placebo.


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