Aspirin plus esomeprazole reduced recurrent ulcer bleeding more than clopidogrel in high-risk patients

Peterson, Walter L.
July 2005
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p24
Academic Journal
This article presents information on a study related to clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. In patients with previous aspirin-induced ulcer bleeding, the addition of esomeprazole to aspirin was better than changing to clopidogrel for decreasing recurrent ulcer bleeding. More patients in the clopidogrel group than in the aspirin-plus-esomeprazole group had recurrent ulcer bleeding. The groups did not differ for lower gastrointestinal bleeding. Adverse event rates for clopidogrel and aspirin plus esomeprazole for extragastrointestinal bleeding were 1.9% and 0%, respectively, for dyspepsia, 7.5% and 2.5%, respectively, for recurrent ischemic events, 5.6% and 6.9%, respectively; and 1.9% for both groups for allergy.


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