Review: High-dose vitamin E supplementation is associated with increased all-cause mortality

Simon, Joel A.
July 2005
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p3
Academic Journal
This article focuses on a study related to high-dose vitamin E supplementation, which is associated with increased all-cause mortality. Randomized controlled trials that compared vitamin E supplementation with a control or placebo group in men or nonpregnant women, study duration and follow-up was 1 year and in this duration 10 deaths occurred. A dose-response analysis showed all-cause mortality increased as vitamin E dose increased 150 IU/d. The effect of vitamin E did not change after adjustment for differences in sex, mean age or mean follow-up. The association of high-dose vitamin E and mortality was stronger after adjustment for concomitant use of other vitamins and minerals.


Related Articles

  • Response to tricyclic antidepressants: independent of gender?  // Current Medical Literature: Psychiatry;2004, Vol. 15 Issue 2, p40 

    Discusses research being done on gender differences in etiology and pathogenesis of depression. Reference to a study by T. Wohlfarth, J. G. Storosum, A. J. Elferink, B. J. Van Zwieten, A. Fouwels and W. Van Den Brink, published in the 2004 issue of the "American Journal of Psychiatry";...

  • Possible new treatment for nonalcoholic steatohepatitis. Constantinescu, Maria Cristina // Maedica - a Journal of Clinical Medicine;2010, Vol. 5 Issue 2, p151 

    The article discusses the study which examines the benefits of pioglitazone, vitamin E, and placebo as the possible new treatment for nondiabetic patients with nonalcoholic steatohepatitis. The clinical trials targets to treat the lobular inflammation and hepatocellular ballooning in a common...

  • Long-term vitamin E doesn't enhance cognitive function.  // Contemporary OB/GYN;Feb2007, Vol. 52 Issue 2, p26 

    The article discusses the results of a trial of vitamin E supplementation and cognitive function in women. A subset of women from the Women's Health Study participated in the study. The researchers observed no differences in global scores between the vitamin E and placebo group. The study found...

  • Gender Differences in 30-Day Mortality for Patients Hospitalized with Acute Pulmonary Embolism. Borrero, Sonya; Aujesky, Drahomir; Stone, Roslyn A.; Geng, Ming; Fine, Michael J.; Ibrahim, Said A. // Journal of Women's Health (15409996);Oct2007, Vol. 16 Issue 8, p1165 

    Background: Prior studies with limited clinical information reported a higher short-term mortality for men than for women with pulmonary embolism (PE). We compared 30-day mortality for men and women hospitalized with PE using a large statewide database. Methods: The sample consisted of 9304...

  • Vitamin E and Cardiovascular Health. Redberg, Rita F. // JAMA: Journal of the American Medical Association;7/6/2005, Vol. 294 Issue 1, p107 

    Presents an editorial about vitamin E and its impact on a patient's cardiovascular health. Discussion of sex and whether one's gender is important in preventing cardiovascular disease; Clinical trials that show health benefits from aspirin for men but not women; Details of a report in this...

  • The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India. Gritz, David C.; Srinivasan, M.; Smith, S. D.; Kim, U.; Lietman, T. M.; Wilkins, J. H.; Priyadharshiniv, B.; John, R. K.; Aravind, S.; Prajna, N. V.; Thulasiraj, R. Duraisami; Whitcher, J. P. // British Journal of Ophthalmology;Jul2006, Vol. 90 Issue 7, p847 

    Aim: To determine if antioxidant supplements (13 carotene and vitamins C and E) can decrease the progression of cataract in rural South India. Methods: The Antioxidants in Prevention of Cataracts (APC) Study was a 5 year, randomised, triple masked, placebo controlled, field based clinical trial...

  • Baseline Characteristics of Participants in the Women's Health Study. Rexrode, Kathryn M.; Lee, I-min; Cook, Nancy R.; Hennekens, Charles H.; Buring, Julie E. // Journal of Women's Health & Gender-Based Medicine;Jan2000, Vol. 9 Issue 1, p19 

    The Women's Health Study (WHS) is a randomized, double-blind, placebo-controlled trial designed to evaluate the balance of benefits and risks of low-dose aspirin and vitamin E in the primary prevention of cardiovascular disease and cancer in women. A total of 39,876 female health professionals,...

  • Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. Kelley, Kristi W.; Carroll, Dana G. // Pharmacy Today;Aug2010, Vol. 16 Issue 8, p59 

    Objective: To review the literature on alternative over-the-counter (OTC) therapies for the treatment of hot flashes in menopausal women. Data sources:A literature search was conducted using PubMed, International Pharmaceutical Abstracts, and Medline from inception to June 2010, combining the...

  • KNOWLEDGE, BELIEFS, AND BEHAVIORS ABOUT HYPERTENSION CONTROL AMONG MIDDLE-AGED KOREAN AMERICANS WITH HYPERTENSION. Hae-Ra Han; Kim, Kim B.; Jeonghee Kang; Seonghee Jeong; Eun-Young Kim; Kim, Miyong T. // Journal of Community Health;Oct2007, Vol. 32 Issue 5, p324 

    This report describes the management and control of high blood pressure (HBP) in a sample of middle-aged (40 to 64 years) Korean Americans (KAs) with HBP. Participants in the Self-Help Intervention Program for HBP care (SHIP-HBP), a culturally tailored clinical trial for HBP management in KAs...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics