TITLE

Review: High-dose vitamin E supplementation is associated with increased all-cause mortality

AUTHOR(S)
Simon, Joel A.
PUB. DATE
July 2005
SOURCE
ACP Journal Club;Jul/Aug2005, Vol. 143 Issue 1, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article focuses on a study related to high-dose vitamin E supplementation, which is associated with increased all-cause mortality. Randomized controlled trials that compared vitamin E supplementation with a control or placebo group in men or nonpregnant women, study duration and follow-up was 1 year and in this duration 10 deaths occurred. A dose-response analysis showed all-cause mortality increased as vitamin E dose increased 150 IU/d. The effect of vitamin E did not change after adjustment for differences in sex, mean age or mean follow-up. The association of high-dose vitamin E and mortality was stronger after adjustment for concomitant use of other vitamins and minerals.
ACCESSION #
18053684

 

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