TITLE

EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE

AUTHOR(S)
Watanabe, N.; Tanada, S.; Sasaki, Y.
PUB. DATE
June 2005
SOURCE
Radiation Protection Dosimetry;2005, Vol. 114 Issue 4, p509
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 tunol kg-1 as a function of its route of administration was investigated in rats with a puncture wound contaminated by 90Y-chloride at a concentration of 2.55 MBq kg-1. Approximately 60% of 90Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of 90Y. Intravenous administration of CaNa3DTPA (systemic treatment) at 15 mm post-puncture reduced 90Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa3DTPA into a puncture wound site (local treatment) at 15 mm post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing 90Y from a puncture wound and minimising 90Y-distribution to bone compared with systemic treatment.
ACCESSION #
18041609

 

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