TITLE

Cold Pressor Test and Hypertension

AUTHOR(S)
Voudoukis, Ignatios J.
PUB. DATE
June 1978
SOURCE
Angiology;Jun1978, Vol. 29 Issue 6, p429
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The cold pressor test was performed on 548 predominantly hypertensive patients seen in a solo private practice from 1967 to the end of 1975. Hypertensive patients and normal individuals had similar cold pressor responses. Patients with arteriosclerosis alone or those with hypertension and superimposed arteriosclerosis were older and had higher cold pressor responses than normals and those with pure hypertension. Analysis of covariance with adjustment for age, however, showed that the exaggerated cold pressor response, seen in pure arteriosclerotics or in those with hypertension and superimposed arteriosclerosis, was independent of age. Although there was a clear-cut association between arteriosclerosis and excessive cold pressor response, other conditions were also found to affect cold pressor response. Patients with severe arteriosclerosis and poor left ventricular performance, following extensive anterior wall myocardial infarction or congestive heart failure, did not have an exaggerated cold pressor response. Similarly, in hypertensive-arteriosclerotic patients taking antihypertensive agents such as methyldopa or propranolol, the cold pressor response was suppressed. On the other hand, nonarteriosclerotic females receiving oral contraceptives or estrogens showed exaggerated cold pressor response. In conclusion, cold pressor response is (1) similar in normals and pure hypertensive patients, (2) exaggerated in arteriosclerotic patients and in females who are not arteriosclerotic but are an oral contraceptives or estrogens, and (3) suppressed in patients with poor left ventricular function and in those receiving sympatholytic agents.
ACCESSION #
18021418

 

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