Joseph, Lester G.; Mancini, A.
June 1961
Angiology;Jun1961, Vol. 12 Issue 6, p264
Academic Journal
Isosorbide dinitrate, a new member of the nitrate series, seems to be a potent coronary vasodilator. It has a rapid onset of action and a duration which seems comparable to other long acting nitrates recommended for coronary vasodilatation. Although the data obtained in this investigation indicate that the drug produces good to excellent results in 80 per cent of the anginal patients in which it was tested, confirmation based on controlled investigations or by the consensus of clinical impressions will be needed to assess accurately the efficacy of this promising new agent.


Related Articles

  • NITROGLYCERIN OINTMENT: A REVIEW. Francis, Gary S.; Hagan, A. D. // Angiology;Dec1977, Vol. 28 Issue 12, p873 

    Presents a review of the efficacy of nitroglycerin ointment, a drug used in the treatment of angina pectoris and in reducing left ventricular end-diastolic and end-systolic volume. Duration of effect of sublingual nitrates; Degradation of oral nitroglycerin agents by hepatic enzymes which result...

  • nitrate drugs. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p547 

    An encyclopedia entry for "nitrate drugs," a group of vasodilator drugs used in treating or preventing attacks of angina pectoris, and treating severe heart failure, is presented. Headaches, flushing of the skin, and dizziness are the possible side effects of nitrate drugs. When some nitrates...

  • Long-Acting Isosorbide Mononitrate: A Viewpoint by John D. Parker. Parker, J.D. // Drugs;Jan1999, Vol. 57 Issue 1, p100 

    Comments on the organic nitrate isosorbide-5-mononitrate. Differences with isosorbide dinitrate; Effectiveness as a treatment for angina pectoris; Examples of long-acting isosorbide-5-mononitrate formulation.

  • Long-Acting Isosorbide Mononitrate: A Viewpoint by Ton J. Cleophas. Cleophas, T.J. // Drugs;Jan1999, Vol. 57 Issue 1, p100 

    Comments on long-acting isosorbide mononitrate as a drug for angina pectoris. Efficacy of the drug; Recommendations on the use of nitrates and other antianginal drugs.

  • Lack of Pharmacologic Tolerance and Rebound Angina Pectoris during Twice-daily Therapy with Isosorbide-5-Mononitrate. Thadani, Udho; Maranda, Claude R.; Amsterdam, Ezra; Spaccavento, Leo; Friedman, Richard G.; Chernoff, Robert; Zellner, Stephen; Gorwit, Jeffrey; Hinderaker, Paul H. // Annals of Internal Medicine;3/1/94, Vol. 120 Issue 5, p353 

    Examines whether isosorbide-5-mononitrate (IS-5-MN), given twice daily, prevents development of tolerance and reduction in exercise performance and its association with a rebound increase in anginal attacks in patients with stable angina pectoris. Development of tolerance during long-term...

  • Pharmacological treatment of chronic stable angina pectoris. Tarkin, Jason M.; Kaski, Juan Carlos // Clinical Medicine;Feb2013, Vol. 13 Issue 1, p63 

    Chronic stable angina is the most common manifestation of ischaemic heart disease in the developed world and is associated with impaired quality of life and increased mortality. The pathogenesis of stable angina is complex and often, albeit not always, involves flow-limiting epicardial coronary...

  • Effects of allopurinol upon exercise in patients with angina. Kuritzky, Louis // Internal Medicine Alert;8/15/2010 Supplement 3, p119 

    The article presents a study on the effects of allopurinol on exercising angina patients.

  • Selection and dosing of nitrates to avoid tolerance during sustained antianginal therapy. Shaw, Sonia V.; Hunter, Walter J.; Shirer, Alyson E. // Formulary;Jul99, Vol. 34 Issue 7, p590 

    Discusses the selection and dosing of nitrates to avoid tolerance during sustained antianginal therapy. Pharmacology; Pharmacokinetics; Nitrate tolerance; Dosage, formulations and pricing; Oral agents; Action; Safety; Regimen selection. INSET: Nitrate therapy: Guidance for formulary decision...

  • Nicorandil and calcium antagonists: remember oro-anal ulceration and reflux cough too. MEDFORD, ANDREW RL // Clinical Medicine;Jun2013, Vol. 13 Issue 3, p323 

    A letter to the editor is presented regarding nicorandil, a drug treatment for stable angina but may present unexplained oro-ulceration, and the risk factor of calcium antagonists which leads to reflux cough due to the fading of the lower oesophageal sphincter and reduced oesophageal clearance.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics