TITLE

THE EFFECTS OF ISOSORBIDE DINITRATE ON CORONARY VASCULAR RESISTANCE

AUTHOR(S)
Buckley, Joseph P.; Aceto, Mario D. G.; Kinnard, William J.
PUB. DATE
June 1961
SOURCE
Angiology;Jun1961, Vol. 12 Issue 6, p259
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Isosorbide dinitrate and pentaerythritol tetranitrate, administered intravenously and intraduodenally to anesthetized dogs, produced marked prolonged hypotensive effects. Both compounds decreased coronary vascular resistance and when the data were statistically analyzed, the responses differed only in that isosorbide dinitrate, administered intraduodenally in tablet form, was more effective in reducing coronary vascular resistance than was pentaerythritol tetranitrate. It is evident that isosorbide dinitrate is an effective vasodilatator, producing maximum effects approximately 80 min. after entering the duodenum. The fact that the coronary blood flow was usually maintained at a rate close to the predrug level, even when isosorbide dinitrate produced marked hypotensive effects, indicates that the compound produced vasodilatory effects on the coronary arteries.
ACCESSION #
18021399

 

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