Sherber, Daniel A.; Gelb, Ira J.
June 1961
Angiology;Jun1961, Vol. 12 Issue 6, p244
Academic Journal
The article discusses clinical effectiveness of the drug isosorbide dinitrate. Given sublingually in reduced dosages, it acts as promptly as nitroglycerin and has a duration of activity of 2 to 3 hours. Adjustment of dosage upward or downward, depending on maximum individual response is possible without any difficulty. Four separate studies using different techniques have determined that isosorbide dinitrate provides good to excellent results in 75 per cent of the patients treated. An additional 20 per cent demonstrate a fair reduction in the frequency and severity of anginal episodes as well as a reduced need for sublingual nitroglycerin.


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