TITLE

Frequency of CCR5 Gene 32-Basepair Deletion in Croatian Normal Population

AUTHOR(S)
Ristić, Smiljana; Čizmarević, Nada Starčević; Brajenović-Milić, Bojana; Crnić-Martinović, Marija; Kapović, Miljenko
PUB. DATE
August 2005
SOURCE
Croatian Medical Journal;2005, Vol. 46 Issue 4, p693
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (CCR5Δ32) could increase the resistance to HIV-1 infection or delayed progression to AIDS. This mutant allele is common among Caucasians of Western European descent, but has not been observed in people of African or Asian ancestry. Genetic studies provided in European countries have shown a highest prevalence in Nordic countries and the lowest in the Southern European and Mediterranean populations. We genotyped 303 randomly selected healthy Croatians for the prevalence of CCR5Δ32 mutation. CCR5Δ32 allele frequency in Croatia of 7.1% fits in the observed European north/south gradient. This first report of CCR5Δ32 mutation in Croatian population provides additional information on its frequency and geographical distribution in Slavic populations in South-Eastern Europe. Moreover, our data may have important implications for the prediction and prevention of HIV/AIDS in a tourist country such as Croatia.
ACCESSION #
18007935

 

Related Articles

  • HIV-Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4+ T Cells in Relation to HIV RNA Load. Oxenius, Annette; Price, David A.; Hersberger, Martin; Schlaepfer, Erika; Weber, Rainer; Weber, Markus; Kunding, Thomas M.; Böni, Jürg; Joller, Helen; Phillips, Rodney E.; Flepp, Markus; Opravil, Milos; Speck, Roberto F. // Journal of Infectious Diseases;4/1/2004, Vol. 189 Issue 7, p1199 

    The average time between infection with human immunodeficiency virus (HIV) and development of acquired immune deficiency syndrome is ∼8 years. However, progression rates vary widely, depending on several determinants, including HIV-specific immunity, host genetic factors, and virulence of...

  • Genomewide Association Study of an AIDSNonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). Limou, Sophie; Le Clerc, Sigrid; Coulonges, Cédric; Carpentier, Wassila; Dina, Christian; Delaneau, Olivier; Labib, Taoufik; Lieng Taing; Sladek, Rob; Deveau, Christiane; Ratsimandresy, Rojo; Montes, Matthieu; Spadoni, Jean-Louis; Lelièvre, Jean-Daniel; Lévy, Yves; Therwath, Amu; Schächter, François; Matsuda, Fumihiko; Gut, Ivo; Froguel, Philippe // Journal of Infectious Diseases;2/1/2009, Vol. 198 Issue 3, p419 

    To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 275 human immunodeficiency virus (HIV) type 1-seropositive nonprogressor patients in relation to a control group of 1352 seronegative individuals in a genomewide association study (GWAS). The...

  • Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1α) gene. Xin, X; Nakamura, K; Liu, H; Nakayama, EE; Goto, M; Nagai, Y; Kitamura, Y; Shioda, T; Iwamoto, A // Genes & Immunity;May2001, Vol. 2 Issue 3, p156 

    Human macrophage inflammatory protein-1 alpha (MIP-1α) is a chemotactic cytokine, which binds to macrophages, T cells, and B cells affecting their activation. We found novel polymorphisms at four sites within MIP-1α gene in Japanese population: C to T in exon 2; A to G in intron 2; C to G...

  • Regulation of CCR5 Expression in Human Placenta: Insights from a Study of Mother-to-Child Transmission of HIV in Malawi. Joubert, Bonnie R.; Franceschini, Nora; Mwapasa, Victor; North, Kari E.; Meshnick, Steven R. // PLoS ONE;2010, Vol. 5 Issue 2, p1 

    Background: Human promoter polymorphisms in the chemokine co-receptor 5 gene (CCR5) have been noted for association with mother-to-child transmission of HIV (HIV MTCT) as well as reduced receptor expression in vitro, but have not been clearly associated with CCR5 expression in vivo. Placental...

  • Association of interleukin 4 VNTR polymorphism and HIV/AIDS in a north Indian seropositive patients. Sobti, Ranbiden; Berhane, Nega; Mahdi, Salih; Takur, Hitnder; Wanch, Ajay // Molecular Biology Reports;Mar2012, Vol. 39 Issue 3, p3251 

    Despite different efforts made to intervene with the deadly nature of HIV/AIDS, all attempts remained unsuccessful due to complexity of the viral host interactions. The solution to HIV-1 pandemic is still to come, thus to assist the efforts being made to intervene with the deadly nature of the...

  • Multiple-Cohort Genetic Association Study Reveals CXCR6 as a New Chemokine Receptor Involved in Long-Term Nonprogression to AIDS. Limou, Sophie; Coulonges, Cédric; Herbeck, Joshua T.; van Manen, Daniëlle; Ping An; Le Clerc, Sigrid; Delaneau, Olivier; Diop, Gora; Lieng Taing; Montes, Matthieu; van't Wout, Angélique B.; Gottlieb, Geoffrey S.; Therwath, Amu; Rouzioux, Christine; Delfraissy, Jean-François; Lelièvre, Jean-Daniel; Lévy, Yves; Hercberg, Serge; Dina, Christian; Phair, John // Journal of Infectious Diseases;9/15/2010, Vol. 202 Issue 6, p908 

    Background. The compilation of previous genomewide association studies of AIDS shows a major polymorphism in the HCP5 gene associated with both control of the viral load and long-term nonprogression (LTNP) to AIDS. Methods. To look for genetic variants that affect LTNP without necessary control...

  • Determination of the CCR2-64I/CCR5-59653T Haplotype Linkage Disequilibrium in a Sample of Polish Population*. Lewandowska, M.; Trzeciak, W.H.; Jagodzinski, P.P. // Russian Journal of Genetics;Jun2003, Vol. 39 Issue 6, p692 

    It has been reported that different polymorphisms in the regulatory regions of CCR5 and in the CCR2 gene of the chemokine receptors are associated with AIDS. We decided to determine the congruence between CCR5-59653T and CCR2-64I alleles in a a group of 281 persons. Frequencies of combined...

  • Genetic Variations in CC Chemokine Receptors and Hypertension. Zhang, Mingdong; Ardlie, Kristin; Wacholder, Sholom; Welch, Robert; Chanock, Stephen; O’Brien, Thomas R. // American Journal of Hypertension;Jan2006, Vol. 19 Issue 1, p67 

    Background: CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32–base pair (bp) deletion (Δ32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among...

  • Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Modi, W. S.; Scott, K.; Goedert, J. J.; Vlahov, D.; Buchbinder, S.; Detels, R.; Donfield, S.; O'Brien, S. J.; Winkler, C // Genes & Immunity;Dec2005, Vol. 6 Issue 8, p691 

    The stromal-derived factor-1 (SDF-1) chemokine gene encodes the only natural ligand for CXCR4, the coreceptor for the pathogenic X4 HIV-1 strains. A single-nucleotide polymorphism (SNP) in the 3′ untranslated region (SDF1-3′A=rs1801157) of SDF-1 was reported to be protective against...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics