TITLE

Association of Vitamin D Receptor Gene Polymorphism with Susceptibility to Graves' Disease in Eastern Croatian Population: Case-control Study

AUTHOR(S)
Štefanić, Mario; Karner, Ivan; Glavaš-Obrovac, Ljubica; Papić, Stana; Vrdoljak, Dubravka; Levak, Gordana; Krstonošić, Branislav
PUB. DATE
August 2005
SOURCE
Croatian Medical Journal;2005, Vol. 46 Issue 4, p639
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim To evaluate the effect of vitamin D3 receptor (VDR)gene Bsml/Apal/Taql restriction fragment length polymorphisms on Graves' disease susceptibility in a subset of patients from Eastern Croatia. Methods Graves' disease patients (n=110) and ethnically matched euthyroid controls (n=99) with no clinical evidence or family history of thyroid or autoimmune diseases were genotyped for VDR gene polymorphisms by Bsm Apa Taq endonuclease digestion after polymerase chain reaction amplification with sequence-specific primers. Data were analyzed by χ²-test, and crude odds ratios (OR)with 95%confidence interval (95%CI)were calculated. Results The Apa "AA" (14.5% vs 30.3%, patients vs controls,respectively, OR=0.39, 95% CI [0.2-0.77 ], P=0.01)and Bsm "BB" (7.3% vs 23.2%, OR=0.26 [0.11-0.61 ], P=0.002) genotypes were significantly underrepresented in patients, whereas Apa "aa" (28.2% vs 9.1%, OR=3.92 [1.76-8.74 ], P=0.001) and Taq "TT" (51.8% vs 31.3%, OR=2.36 [1.34-4.16 ], P=0.004) genotypes were significantly more frequent in patients than controls. The genotype combination, which conferred the strongest protection against Graves' disease, was "BBAAtt" (2.7% vs 17.2%, OR=0.14 [0.04-0.48 ], P= 0.001). Conclusion These findings suggest that VDR gene Bsml/Apal/Taql polymorphisms are associated with Graves' disease susceptibility in a subset of patients from Eastern Croatia. The Apa Bsm "AA" and "BB" genotypes, respectively, as well as combined "BBAAtt" genotype, appeared to confer protection against Graves' disease, whereas Apa "aa" and Taq "TT" genotypes were associated with an increased risk for Graves' disease. However, the true mechanisms of association remain to be elucidated.
ACCESSION #
18007908

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics