TITLE

Reemergence of Hepatitis C Virus after 8.5 Years in a Patient with Hypogammaglobulinemia: Evidence for an Occult Viral Reservoir

AUTHOR(S)
Lee, William M.; Polson, Julie E.; Carney, D. Spencer; Sahin, Bogachan; Gale, Jr., Michael
PUB. DATE
September 2005
SOURCE
Journal of Infectious Diseases;9/15/2005, Vol. 192 Issue 6, p1088
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The question of whether viruses persist after apparent clearance of infection remains unanswered. Here, we describe a patient with hypogammaglobulinemia whose acute hepatitis C virus (HCV) infection appeared to resolve after receipt of interferon therapy, relapse immediately, and then clear spontaneously—only to relapse after receipt of corticosteroid therapy, and clear again, 8.5 years later. Sequencing indicated that the viruses detected during each relapse were virtually identical, with the hypervariable region 1 of E2 appearing to be monoclonal, which is typical of patients with hypogammaglobulinemia. Nonstructural 5A sequences exhibited quasispecies diversity initially but, after 8.5 years, had become monoclonal. The prolonged period of negativity for HCV RNA followed by relapse suggests that HCV may persist in apparent sustained viral responders.
ACCESSION #
17988624

 

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