A Prospective Study Comparing Human Metapneumovirus with Other Respiratory Viruses in Adults with Hematologic Malignancies and Respiratory Tract Infections

Williams, John V.; Martino, Rodrigo; Rabella, Núria; Otegui, Magdalena; Parody, Rocio; Heck, Joshua M.; Crowe, Jr., James E.
September 2005
Journal of Infectious Diseases;9/15/2005, Vol. 192 Issue 6, p1061
Academic Journal
Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain re- action for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. IIMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality.


Related Articles

  • Apartment complex holds clues to pandemic potential of SARS. Cyranoski, David; Abbott, Alison // Nature;5/1/2003, Vol. 423 Issue 6935, p3 

    Reports that an apartment block in Kowloon district of Hong Kong, China could provide clues to the true risk posed by severe acute respiratory syndrome (SARS). Investigation of the extent to which people without symptoms are carrying SARS; Conduction of tests using a version of the polymerase...

  • Multiplex SYBR Green Real-Time PCR Assay for Detection of Respiratory Viruses. Sultani, Mozhdeh; Azad, Talat Mokhtari; Eshragian, Mohammadreza; Shadab, Azadeh; Naseri, Maryam; Eilami, Owrang; Yavarian, Jila // Jundishapur Journal of Microbiology;Aug2015, Vol. 8 Issue 8, p1 

    Background: It is often difficult for a physician to distinguish between viral and bacterial causes of respiratory infections and this may result in overuse of antibiotics. In many cases of community-acquired respiratory infections, clinicians treat patients empirically. The development of...

  • Effectiveness of Inactivated Influenza Vaccines Varied Substantially with Antigenic Match from the 2004-2005 Season to the 2006-2007 Season. Belongia, Edward A.; Kieke, Burney A.; Donahue, James G.; Greenlee, Robert T.; Balish, Amanda; Foust, Angie; Lindstrom, Stephen; Shay, David K. // Journal of Infectious Diseases;1/15/2009, Vol. 199 Issue 2, p159 

    Background. We estimated the effectiveness of inactivated influenza vaccines for the prevention of laboratory confirmed, medically attended influenza during 3 seasons with variable antigenic match between vaccine and patient strains. Methods. Patients were enrolled during or after a clinical...

  • Molecular detection of human rhinoviruses in respiratory samples: a comparison of Taqman probe-, SYBR green I- and BOXTO-based real-time PCR assays. Dupouey, Julien; Ninove, Laetitia; Ferrier, Vanessa; Py, Odile; Gazin, Céline; Thirion-Perrier, Laurence; de Lamballerie, Xavier // Virology Journal;2014, Vol. 11 Issue 1, p1 

    Background Human Rhinoviruses (HRV) are major causative agents of acute respiratory tract infections in all age group and important contributing factors of childhood morbidity and mortality. Clinical presentation is poorly specific and the great antigenic and genetic variability of HRVs renders...

  • Serum Procalcitonin Level, Viral Polymerase Chain Reaction Analysis, and Lower Respiratory Tract Infection. Musher, Daniel M.; Bebko, Serge P.; Roig, Ingrid L. // Journal of Infectious Diseases;Feb2014, Vol. 209 Issue 4, p631 

    A letter to the editor is presented in response to the article "Bacterial complications of respiratory tract viral illness: a comprehensive evaluation" by A.R. Falsey and colleagues in a 2013 issue.

  • Detection of three human adenovirus species in adults with acute respiratory infection in China. Guo, L.; Gonzalez, R.; Zhou, H.; Wu, C.; Vernet, G.; Wang, Z.; Wang, J. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2012, Vol. 31 Issue 6, p1051 

    Human adenoviruses (HAdVs) are recognized as causal agents in a wide range of human diseases. However, researchers lack sufficient data on the exact HAdV species and serotypes associated with adult acute respiratory tract infections (ARTIs). To detect and characterize HAdV infections in adults...

  • Serodiagnosis of Human Bocavirus Infection. Kantola, Kalle; Hedman, Lea; Allander, Tobias; Jartti, Tuomas; Lehtinen, Pasi; Ruuskanen, Olli; Hedman, Klaus; Söderlund-Venermo, Maria // Clinical Infectious Diseases;2/15/2008, Vol. 46 Issue 4, p540 

    Background. A new human-pathogenic parvovirus, human bocavirus (HBoV), has recently been discovered and associated with respiratory disease in small children. However, many patients have presented with low viral DNA loads, suggesting HBoV persistence and rendering polymerase chain reaction-based...

  • Identification of Risk Factors for Infection in an Outbreak of Mycoplasma pneumoniae Respiratory Tract Disease. Klement, Eyal; Talkington, Deborah F.; Wasserzug, Oshri; Kayouf, Raid; Davidovitch, Nadav; Dumke, Roger; Bar-Zeev, Yael; Ron, Merav; Boxman, Jonathan; Thacker, W. Lanier; Wolf, Dana; Lazarovich, Tsilia; Shemer-Avni, Yonat; Glikman, Daniel; Jacobs, Enno; Grotto, Itamar; Block, Colin; Nir-Paz, Ran // Clinical Infectious Diseases;11/15/2006, Vol. 43 Issue 10, p1239 

    Background. Mycoplasma pneumoniae is one of the most common pathogens that causes community-acquired respiratory tract infection. Outbreaks are well known, and all age groups are susceptible. An outbreak in an army training unit afforded an opportunity to identify possible risk factors for...

  • Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong. Malik Peiris, J.S.; Wing-Hong Tang; Kwok-Hung Chan; Pek-Lan Khong; Yi Guan; Yu-Lung Lau; Chiu, Susan S. // Emerging Infectious Diseases;Jun2003, Vol. 9 Issue 6, p628 

    Focuses on a study which examined several children hospitalized with human metapneumovirus (HMPV) respiratory infection over a certain period. Detection of HMPV in the nasopharyngeal aspirates by reverse transcription-polymerase chain reaction; Association of HMPV with clinical diagnoses of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics