TITLE

Suppressor αβ T Lymphocytes Control Innate Resistance to Endotoxic Shock

AUTHOR(S)
Jones-Carson, Jessica; Fantuzzi, Giamila; Siegmund, Britta; Dinarello, Charles; Tracey, Kevin J.; Wang, Haichao; Fang, Ferric C.; Vazquez-Torres, Andres
PUB. DATE
September 2005
SOURCE
Journal of Infectious Diseases;9/15/2005, Vol. 192 Issue 6, p1039
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A considerable amount of research has focused on elucidating the mechanisms by which cytokines synthesized by cells of the innate immune system participate in the life-threatening multiple-organ failure of endotoxic shock. We show here that αβ T cells, which are archetypes of the adaptive cellular immune response, suppress the proinflammatory cascade triggered during the early stages of lipopolysaccharide (LPS)-induced endotoxemia. The absence of αβ T cells led to the fulminant death of LPS-challenged mice, coinciding with a massive release of the proinflammatory cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-αγ and a marked reduction in the synthesis of the immunosuppressive cytokine transforming growth factor (TGF)-β. Cytotoxic T lymphocyte antigen (CTLA)-positive αβ T cells emerging shortly after LPS challenge appear to control TGF-β synthesis. The neutralization of either TGF-β or CTLA4 resulted in similar increases in IFN-αγ and TNF-α serum concentrations in LPS-challenged mice. These observations suggest that suppressor αβ T lymphocytes protect against the pro inflammatory cascade unleashed during the innate stages of endotoxemia.
ACCESSION #
17988602

 

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