LUNG ALERT: Premedication with zolpidem may reduce poor quality polysomnography

Bhatia, P.
August 2005
Thorax;Aug2005, Vol. 60 Issue 8, p703
Academic Journal
This article presents information on a clinical study which showed that premedication with the drug zolpidem may reduce poor quality polysomnography (PSG). The increasing awareness of sleep disordered breathing has resulted in an increased demand for PSG. Zolpidem is a non-benzodiazepine sedative which has been shown to decrease sleep latency and increase sleep efficiency with minimal side effects on sleep architecture and respiratory events. The authors hypothesised that premedication with zolpidem before PSG might therefore result in a higher diagnostic yield. They retrospectively reviewed 203 PSGs performed in adults. Two were excluded because they were given 5 mg zolpidem and one was excluded because he was on long term zolpidem treatment. Zolpidem premedication was not standardised and was prescribed at the discretion of the consulting sleep physicians who were unaware of the study.


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