LUNG ALERT: N-Acetylcysteine and disease progression in COPD

Sotkunam, K.
August 2005
Thorax;Aug2005, Vol. 60 Issue 8, p622
Academic Journal
This article presents results of a clinical study in which the antioxidant N-acetylcysteine was used to assess whether this drug could reduce the rate of lung function decline, reduce the yearly exacerbation rate, or improve clinical outcomes of chronic obstructive pulmonary disease (COPD). 523 patients were randomised to receive either 600 mg NAC daily or placebo over a 3 year period. Further subgroup analysis did suggest that there may be a benefit of the exacerbation rate in those patients not treated with inhaled steroids. This study has shown that NAC when given at this dose does not reduce the rate of decline in lung function or reduce exacerbation rate in patients with COPD.


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