A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression

Benigni, Ariela; Zoja, Carla; Corna, Daniela; Orisio, Silvia; Longaretti, Lorena; Bertani, Tullio; Remuzzi, Giuseppe
August 1993
Kidney International;Aug1993, Vol. 44 Issue 2, p440
Academic Journal
We have recently reported that renal preproendothelin-1 gene is up-regulated in rats with renal mass reduction (RMR) and that time-dependent increase in urinary excretion of the corresponding peptide correlates with renal disease progression. Here we evaluated whether a specific endothelin subtype A (ETA) receptor antagonist, FR139317, reduced signs of disease activity in this model. Two groups of rats were given FR139317 or its vehicle (saline) from day 7 to day 60 after the surgical procedure. Sham-operated animals were the control group. Blood pressure, urinary protein excretion and serum creatinine were evaluated at days 0, 7 (before FR139317 or saline administration), 30, 45 and 60. At sacrifice, histological evaluation of renal tissue was performed. The results showed that ETA receptor blocker reduced the abnormal permeability to proteins, limited glomerular injury and prevented renal function deterioration thus confirming the working hypothesis. These findings suggest that this class of compounds may eventually prove useful in the treatment of human progressive nephropathies.


Related Articles

  • A Clinicopathological Study of C1q Nephropathy at King Abdulaziz University. Mokhtar, Ghadeer A.; Jalalah, Sawsan M. // Iranian Journal of Kidney Diseases;Jul2015, Vol. 9 Issue 4, p279 

    Introduction. C1q nephropathy is a relatively rare idiopathic glomerulopathy characterized by mesangial immunoglobulin and complement deposits with dominance or co-dominance of C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, clinical manifestation,...

  • Chronic Kidney Disease and the Risk of Cardiovascular Disease Events: A Community-Based Approach. Iseki, Kunitoshi; Iseki, Chiho; Okumura, Koichiro; Kinjo, Kozen; Takishita, Shuichi // Vascular Disease Prevention;Oct2006, Vol. 3 Issue 4, p327 

    Chronic kidney disease (CKD) is a new cardiovascular disease risk factor. However, few epidemiological studies examined the relationship between CKD and the risk of developing cardiovascular disease (CVD) in a general population. We evaluated the significance of CKD on the incidence of CVD by...

  • Diferencias de la ecuación CKD-EPI con la de MDRD para la estimación del filtrado glomerular en pacientes hipertensos. Marcos, M. A. Gómez; Sánchez, E. Rodríguez; Rodríguez, J. I. Recio; Cantera, C. Martín; Blanes, R. Ramos; Ortiz, L. García // Nefrologia;Aug2010, Vol. 30 Issue 4, p458 

    Objective: To analyze the agreement in glomerular filtration rate (GFR) estimated with CKD-EPI and MDRD-IDMS equations in a cohort of hypertensive patients. Methods: We included consecutively 478 hypertensive patients, 57.58 (SD: 12.34) aged, 68.3% males. The estimation of GFR was performed with...

  • Progression of renal insufficiency: Role of blood pressure. Brazy, Peter C.; Stead, William C.; Fitzwilliam, James F. // Kidney International;Feb1989, Vol. 35 Issue 2, p670 

    The effect of blood pressure on progression of renal insufficiency was examined in a large group of patients who eventually required dialysis. Out of 198 consecutive new chronic dialysis patients, 86 had sufficient data predialysis to determine rates of progression of renal insufficiency by...

  • Controlling BP, For These Men, Can Maintain Kidney Function.  // RN;Nov2000, Vol. 63 Issue 11, p18 

    Highlights the results of a study on the relation between blood pressure (BP) and serum creatinine (a measure of kidney function) in young adults from a biracial community. Ability of young black men to prevent kidney disease by controlling BP; Study at Tulane University Medical Center.

  • The Role of Diabetic Mellitus (DM) Control on Renal Function's Outcome in DM Patients (DMP) in a Large Network of Primary Care Physicians. Meyerovitch, Joseph; Bartal, Orna; Bernheim, Jacques; Golan, Eliezer; Sherf, Michael // Diabetes;Jun2007 Supplement 1, Vol. 56, pA609 

    Clalit Health Services (CHS) is a Health Medical Organization (HMO) with 3.7 million members, of which 225,000 (6%) are Diabetes Mellitus Patients (DMP). Preserving the renal function (RF) of DMP is one of the primary aims of the organization. This observational study, based on a large...

  • Endothelins in diabetic kidneys. Koide, Hikaru; Nakamura, Tsukasa; Ebihara, Isao; Fukui, Mitsumine // Kidney International Supplement;Sep1995, Issue 51, pS-45 

    Presents a study which investigates the role of endothelin (ET) in diabetic kidneys. Identification of ET as a potent vosoconstrictor peptide originally isolated and purified from the conditioned medium of cultured porcine aortic endothelial cells; Capacity of ET to induce a long-lasting...

  • Increased ETA and ETB receptor contraction in the left internal mammary artery from patients with hypertension. Nilsson, D.; Wackenfors, A.; Gustafsson, L.; Edvinsson, L.; Paulsson, P.; Ingemansson, R.; Malmsj�, M. // Journal of Human Hypertension;Mar2008, Vol. 22 Issue 3, p226 

    The article discusses a study that shows enhanced endothelin type A and type B receptor contraction and expression in the left internal mammary artery from patients with hypertension as compared to normotensive patients. Results reveal that both endothelin type A and type B receptors are...

  • Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. Orisio, Silvia; Benigni, Ariela; Bruzzi, Isabella; Corna, Daniela; Perico, Norberto; Zoja, Carla; Benatti, Luca; Remuzzi, Giuseppe // Kidney International;Feb1993, Vol. 43 Issue 2, p354 

    We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics