Failure to predict cyclosporine area under the curve using a limited sampling strategy

Gaspari, Flavio; Ruggenenti, Piero; Torre, Leonarda; Bertocchi, Cesare; Remuzzi, Giuseppe; Perico, Norberto
August 1993
Kidney International;Aug1993, Vol. 44 Issue 2, p436
Academic Journal
Studies the pharmacokinetic profile of cyclosporin A (CsA) that correlated best with the area under the time-concentration curve in renal transplant patients. Manifestation of renal toxicity as an acute reduction in the glomerular filtration rate or as chronic vasculopathy and interstitial fibrosis; Factors attributed to the limitation of trough level monitoring; Measurement of CsA concentrations by a high-performance liquid chromatographic method.


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