TITLE

T cell activation defect in hemodialysis patients: Evidence for a role of the B7/CD28 pathway

AUTHOR(S)
Girndt, Matthias; Köhler, Hans; Schiedhelm-Weick, Erika; zum Buüschenfelde, Karl-Hermann Meyer; Fleischer, Bernhard
PUB. DATE
August 1993
SOURCE
Kidney International;Aug1993, Vol. 44 Issue 2, p359
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The immunosuppressive effect of chronic renal failure is correlated with an impaired proliferation of peripheral blood leukocytes in vitro. This is mainly due to an impaired function of the accessory cells rather than the T cells. Here we tried to define a missing accessory signal for T cell activation in hemodialysis patients. We substituted cell surface bound molecules by adding tumor cell lines to the in vitro assays that express different patterns of accessory molecules. Cell lines that express the costimulatory B7 molecule reconstituted the activation of patients' cells whereas B7 negative cells did not. The reconstitution was also achieved using mouse fibroblasts transfected with human B7 or by monoclonal antibodies that stimulate the B7 ligand CD28 on T cells. These data further emphasize that impaired leukocyte function in renal failure is due to an accessory cell defect, and that T cells of these patients have normal functional capacities when they get the costimulatory signals required. We demonstrate that it is the B7/CD28 pathway that reconstitutes cellular functions in the patients. However, the short-term suppressive effects of uremic serum cannot be compensated by additional costimulation via B7/CD28.
ACCESSION #
17967190

 

Related Articles

  • French Society of Nephrology.  // Kidney International;Sep1983, Vol. 24 Issue 3, p404 

    Presents abstracts of articles published in the journal "Kidney International." "Hemodialysis Biocompatibility: Evaluation of Dialysale and Membranes Respective Blood Interactions," by B. Branger, R. Oules, C. Granolleras, G. Deschodt, D. Treissede, S. Shaldon, and H. Mion; "In Vitro Studies of...

  • Abstracts.  // Kidney International;Mar1988, Vol. 33 Issue 3, p755 

    Presents abstracts of articles published in the March 1987 issue of "Kidney International." "Determination of Etylendioxid IgE Antibodies in a Group of Patients on Hemodialysis," by S. Karlsson and colleagues; "Acute Hemodynamic Changes in the Passive Heymann Nephritis (PHN) is Mediated by the...

  • Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure. Solez, Kim; Kramer, Elizabeth C.; Fox, Jennifer A.; Heptinstall, Robert H. // Kidney International;Jul1974, Vol. 6 Issue 1, p24 

    The accumulation of nucleated cells in the vasa recta in acute renal failure has been attributed to intravascular hematopoiesis caused by reduced medullary blood flow. Medullary plasma flow was determined in rats with HgCl2- induced acute renal failure by infusing 125I-albumin i.v. for 15 or 30...

  • High FGF-23 in AKI Raises Death Rises. Charnow, Jody A. // Renal & Urology News;Dec2011, Vol. 10 Issue 12, p1 

    The article reports on the result of a study which shows that the increased levels of fibroblast growth factor 23 (FGF-23) in acute kidney injury (AKI) are linked with an increased risk of death or need for renal replacement therapy (RRT).

  • Acute hemodialysis of infants weighing less than five kilograms. Sadowski, Robert H.; Harmon, William E.; Jabs, Kathy // Kidney International;Mar1994, Vol. 45 Issue 3, p903 

    The records of 33 infants weighing 5 kg or less who received acute hemodialysis treatment at Children's Hospital between 1980 and 1991 were reviewed. Dialysis was initiated to treat hyperammonemia (8), primary renal or renovascular disease (7), and acute renal failure (18). The infants weighed...

  • Steal syndrome complicating upper extremity hemoaccess procedures: incidence and risk factors. Davidson, Dion; Louridas, George; Guzman, Randolph; Tanner, John; Weighell, Wendy; Spelay, Jodi; Chateau, Dan // Canadian Journal of Surgery;Dec2003, Vol. 46 Issue 6, p408 

    Steal syndrome is a potentially grave complication of upper extremity hemoaccess (HA) in patients with renal failure. To determine the incidence and risk factors for steal in these patients at the St. Boniface Hospital, Winnipeg, a tertiary care centre for vascular surgery and dialysis, we...

  • ACUTE RENAL FAILURE IN A TERTIARY CARE CENTER IN NEPAL. Khakurel, S.; Satyal, P. R.; Agrawal, R. K.; Chhetri, P. K.; Hada, R. // Journal of the Nepal Medical Association;Apr-Jun2005, Vol. 44 Issue 158, p32 

    From July 1998 to July 1999, 45 cases of acute renal failure were treated at Bir Hospital, Kathmandu. Out of which 24 were male and 21 were female. Age ranged from 11 months to 84 years with mean age being 35 years and 9 cases were below 10 years. Four cases with pre-renal azotaemia and twenty...

  • Dialysis for surgical acute renal failure. Davison, Alex M. // Journal of the Royal Society of Medicine (Supplement);Jul1996, Vol. 89 Issue 29, p17 

    The article examines the application of hemodialysis as part of a management regimen for acute renal failure. The most common causes of acute renal failure are the reduction of renal perfusion from diminished intravascular volume, toxic causes from sepsis and nephrotoxic drugs and pre-existing...

  • The Case ∣ Cranial nerve palsy and acute renal failure after a ‘special drink’. Morelle, Johann; Kanaan, Nada; Hantson, Philippe // Kidney International;Mar2010, Vol. 77 Issue 6, p559 

    The article presents the case study of a 40-year-old man who was suffering with abdominal pain, diarrhea, and progressive oligo-anuria. Initial diagnosis revealed acute renal failure and anion-gap metabolic acidosis. Further examination showed that it was a case of toxic alcohol ingestion and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics