TITLE

Control of aldosterone responsiveness in terminal renal failure

AUTHOR(S)
Weidmann, Peter; Maxwell, Morion H.; de Lima, José; Hirsch, David; Franklin, Stanley S.
PUB. DATE
January 1975
SOURCE
Kidney International;Jan1975, Vol. 7 Issue 1, p351
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Plasma aldosterone concentration in 30 hemodialysis patients correlated closely with renin concentration, renin activity or renin and potassium concentrations combined (r ⩾ 0.62; P < 0.01), and increased consistently in response to upright posture or corticotropin administration. Aldosterone response to hemodialysis was variable, Significant correlations (r ⩾ 0.65; P < 0.01) were demonstrated between postural plasma aldosterone and renin responses, between aldosterone responses to corticotropin and basal plasma aldosterone or renin and potassium values, between hemodialysis-induced changes in plasma aldosterone and those in potassium or renin; but not between various indexes of heparin treatment and aldosterone activity. Bilateral nephrectomy reduced basal plasma renin and aldosterone concentrations and aldosterone responsiveness in five preoperatively normoreninemic or hyperreninemic patients, but not in a hyporeninemic patient. These results demonstrate the complementary roles of circulating renin and potassium in the control of aldosterone release under basal and stimulatory conditions in patients with terminal renal failure. Administration of heparin in dosages used during long-term hemodialysis does not appear to significantly interfere with aldosterone control.
ACCESSION #
17965912

 

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