Nature of the acidifying defect after the relief of ureteral obstruction

Walls, John; Buerkert, John E.; Purkerson, Mabel L.; Klahr, Saulo
January 1975
Kidney International;Jan1975, Vol. 7 Issue 1, p304
Academic Journal
The acidifying capacity of the normal and experimental kidney was studied in rats three hours after release of complete unilateral ureteral obstruction or after unilateral release of bilateral ureteral obstruction. In seven rats following release of unilateral ureteral obstruction, mean plasma bicarbonate concentration was 23.5 mEq/liter, and plasma pH, 7.45. Urine pH from the postreleased kidney was 7.47 and 6.01 from the control side. Net acid excretion averaged 0.97 ± 0.14 μEq/min in the control and -0.17 ± 0.05 μEq/min in the experimental kidney. Fractional excretion of bicarbonate averaged 0.02% in the control and 3.17% in the experimental kidney. In eight animals with unilateral release of bilateral ureteral obstruction, mean plasma bicarbonate was 16.9 mEq/liter and plasma pH was 7.35. Mean urine pH in the postreleased kidney was 6.11, net acid excretion averaged 2.01 ± 0.69 μEq/min and fractional bicarbonate excretion averaged 0.84%. A third group of animals received ammonium chloride prior to release of unilateral ureteral obstruction. In these animals mean plasma bicarbonate concentration was 16.9 mEq/liter, and plasma pH, 7.32. Urine pH was 5.70 in the control and 5.79 in the experimental kidney. Bicarbonate titration studies in four animals after release of unilateral ureteral obstruction failed to demonstrate a Tm for bicarbonate in either the experimental or control kidney. There was no evidence for an increased splay in the bicarbonate titration curves. Micropuncture experiments failed to demonstrate decreased bicarbonate reabsorption after release of unilateral ureteral ligation in surface nephrons. Urinary PCO2 values remained low after bicarbonate loading in the experimental kidney of rats subjected to release of unilateral ureteral ligation. It is suggested that the acidifying defect may be due to decreased H+ secretion in the distal and collecting duct of surface nephrons or to marked alteration in the reabsorption of bicarbonate in juxtamedullary nephrons.


Related Articles

  • The Burden of Ureteropelvic Junction Obstruction in the United States. Lam, John S.; Schulam, Peter G. // AUANews;Jul2007, Vol. 12 Issue 7, p11 

    The article offers a look at the prevalence of ureteropelvic junction obstruction (UPJO) in the U.S. UPJO is a condition referring to a blockage at the junction of the renal pelvis and the ureter, which causes prenatal and neonatal hydronephrosis. Between 1997 and 2000, hospitalization rates for...

  • Comparison of flexible ureterorenoscopy and micropercutaneous nephrolithotomy in the treatment for moderately size lower-pole stones. Armagan, Abdullah; Karatag, Tuna; Buldu, Ibrahim; Tosun, Muhammed; Basibuyuk, Ismail; Istanbulluoglu, Mustafa; Tepeler, Abdulkadir // World Journal of Urology;Nov2015, Vol. 33 Issue 11, p1827 

    Purpose: To present a retrospective comparative clinical study of micropercutaneous nephrolithotomy (microperc) versus flexible ureterorenoscopy (F-URS) in treatment of moderate-size lower-pole stones (LPSs). Methods: We retrospectively reviewed data on patients with isolated LPSs ≤2 cm in...

  • Effects of chronic acid fog exposure with soil acidification or nitrogen loading on nutrient status inAbies firmaseedlings. Yoshida, Koji; Inaba, Shoko; Takenaka, Chisato; Tezuka, Takafumi // Journal of Forest Research;Apr2005, Vol. 10 Issue 2, p157 

    To clarify the nutrient status in momi fir (Abies firmaSieb. et Zucc.) seedlings under complex stress conditions of acid fog with soil acidification or nitrogen loading, we exposed seedling shoots to simulated acid fog (pH 3) and simultaneously loaded the soil with acid or excess nitrogen for 17...

  • Description of the Ocean Acidification Database Tables.  // CO2 Science;10/10/2012, Vol. 15 Issue 41, p7 

    The article focuses on the Ocean Acidification Database. It cites the content of the database and how the data are arranged. It discusses two data tables including one on statistical information and one on individual experimental results. It describes various categories of seawater pH decline...

  • The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activity. Preisig, P. A. // Kidney International;Dec2007, Vol. 72 Issue 11, p1324 

    On a typical Western diet, the body is faced with the generation of a metabolically derived acid load that must be excreted to maintain systemic acid–base balance. The kidney is responsible for this task and matches daily acid excretion with daily acid production. Multiple nephron...

  • Basolateral Na+/H+ exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct. Muto, Shigeaki; Tsuruoka, Shuichi; Miyata, Yukio; Fujimura, Akio; Kusano, Eiji; WenHui Wang; Seldin, Donald; Giebisch, Gerhard // Kidney International;Jan2009, Vol. 75 Issue 1, p25 

    Stimulation of the basolateral Na+/K+-ATPase in the isolated perfused rabbit cortical collecting duct by raising either bath potassium or lumen sodium increases potassium secretion, sodium absorption and their apical conductances. Here we determined the effect of stimulating Na+/K+-ATPase on...

  • Sea Urchin Larvae Living in Periodically Low-pH Seawater.  // CO2 Science;8/10/2010, p1 

    The article presents a study on the periodic presence of sea urchin larvae in low pH seawater. The authors of the study deployed a SeaFET pH sensor from July 22 to August 17, 2011 at Mohawk Reef in Santa Barbara, California and raised larvae of the purple sea urchin in seawater. Changes up to...

  • Thermally stratified acid water in late winter - a key factor inducing self-accelerating processes which increase acidification. Hultberg, Hans // Water, Air & Soil Pollution;Mar1977, Vol. 7 Issue 3, p279 

    Ion separation of acid air pollutants out of snow causes sudden, deep pH-drops in lakes and running waters at an early stage of snowmelting. These pH-drops have drastic effects on fish populations and are suggested to be the main cause of Sphagnum invasion and changes in the microflora already...

  • Factors influencing the acid�base (pH) balance in the Baltic Sea: a sensitivity analysis. OMSTEDT, ANDERS; EDMAN, MOA; ANDERSON, LEIF G.; LAUDON, HJALMAR // Tellus: Series B;Sep2010, Vol. 62 Issue 4, p280 

    Using calculations based on the marine carbon system and on modelling, the sensitivity of Baltic Sea surface pH was examined. Transient long-term calculations demonstrated that the marine carbon system adjusts to lateral boundary conditions within some decades, as does salinity. Climate changes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics