TITLE

Tubular and interstitial renal disease due to immunologic mechanisms

AUTHOR(S)
Andres, Giuseppe A.; McCluskey, Robert T.
PUB. DATE
January 1975
SOURCE
Kidney International;Jan1975, Vol. 7 Issue 1, p271
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study on the generation of tubular and interstitial lesions immunologic mechanisms. Tubular and interstitial lesions can result from immune complexes or from autoantibodies against tubular basement membrane constituents. The functional importance of these tubular deposits and the associated tubular and interstitial lesions remain to be evaluated. However, several patients have been found to have glucosuria with normal blood sugar concentrations. Researchers observed that the tubular deposits and associated tubular and interstitial changes may be partially responsible for renal functional impairment.
ACCESSION #
17965830

 

Related Articles

  • In This Issue.  // Kidney International;Jul2012, Vol. 82 Issue 2, p119 

    The article presents abstracts of several studies on kidney diseases published in the current issue including targeted proximal tubular injury, increased dietary sodium, and autoantibodies.

  • Anti-C1q autoantibodies, novel tests, and clinical consequences. Mahler, Michael; van Schaarenburg, Rosanne A.; Trouw, Leendert A. // Frontiers in Immunology;May2013, Vol. 4, p1 

    Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening. By far the largest set of studies focus on anti-C1q antibodies...

  • Monoclonal antibodies and identification of glomerular antigens. Verroust, Pierre; Ronco, Pierre Marie; Chatelet, François // Kidney International;Nov1986, Vol. 30 Issue 5, p649 

    Studies monoclonal antibodies (Mab) and identification of glomerular antigens. Usefulness of Mab production coupled to antigen identification; Characterization of several of the basement membrane (BM) antigens involved in anti-glomerular BM; Isolation of the antigen responsible for Heymann's...

  • The relevance of antigen binding to the pathogenicity of lupus autoantibodies. Madaio, Michael P // Kidney International;Jul2012, Vol. 82 Issue 2, p125 

    Although lupus autoantibodies provide diagnostic value, discordance between serum levels and nephritis poses mechanistic questions. Krishnan and co-workers report that only those that crossreact with basement membrane components produce immune deposits. Thus, other glomerular binding properties...

  • Nephrotoxic canine glomerulonephritis. McPhaul, Jr., John J.; Grey, Glenn J.; Wagner, Daniel F.; MacKenzie, William F. // Kidney International;Jul1974, Vol. 6 Issue 1, p123 

    The article presents information on a study that examined nephrotoxic nephritis in dogs. In the study, adult outbred mongrel dogs were used. Routine blood chemistry determinations were performed on an autoanalyzer. Dogs immunized actively with human antiglomerular basement membrane antibodies...

  • Antibodies to tubular basement membrane elicited by stimulation with allogeneic kidney. Sugisaki, Tetsuzo; Kano, Kyoichi; Andres, Giuseppe; Milgrom, Felix // Kidney International;Apr1982, Vol. 21 Issue 4, p557 

    It has been shown that Brown-Norway (BN) rats injected with homologous tubular basement membrane (TBM) preparations develop TBM antibodies and tubulointerstitial nephritis (TIN). TBM antigen(s) under study was expressed in BN rats and (MAXX × BN)F1 hybrids but was lacking in MAXX rats. (MAXX...

  • Goodpasture antigen: Expression of the full-length α3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. LEINONEN, ANU; NETZER, KAI-OLAF; BOUTAUD, ARIEL; GUNWAR, SRIPAD; HUDSON, BILLY G.; Hudson, Billy G. // Kidney International;Mar1999, Vol. 55 Issue 3, p926 

    Goodpasture antigen: Expression of the full-length α3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. Background. Tissue injury in Goodpasture (GP) syndrome (rapidly progressive glomerular nephritis and pulmonary hemorrhage) is mediated by...

  • TSH Receptor Antibodies. Bernard Rees Smith; Jane Sanders; Jadwiga Furmaniak // Thyroid;Oct2007, Vol. 17 Issue 10, p923 

    The discovery of thyroid-stimulating autoantibodies by Adams and Purves 50 years ago was one of the most important observations in the history of thyroidology. Since that time, the thyroid-stimulating hormone receptor (TSHR) has been shown to be the antigen recognized by these autoantibodies...

  • MMF does improve proteinuria in some MN patients.  // Kidney;Jan/Feb2001, Vol. 10 Issue 1, p17 

    Presents an abstract of the study 'Use of Mycophenolate Mofetil in Resistant Membranous Nephropathy,' by G. Miller, R. Zimmerman III, J. Radhakrishnan et al.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics