Renal function after release of chronic unilateral hydronephrosis in man

Gillenwater, Jay Y.; Westervelt, Jr., Frederic B.; Vaughan, Jr., E. Darracott; Howards, Stuart S.
January 1975
Kidney International;Jan1975, Vol. 7 Issue 1, p179
Academic Journal
Differential renal function studies performed on ten patients after release of unilateral hydronephrosis revealed that the previously obstructed kidney exhibits abnormalities in a number of physiological indexes. Many of the obstructed kidneys had an impairment of glomerular filtration rate, concentrating ability, acidification, sodium reabsorption and tubular maximal secretion of para-aminohippurate with normal urinary dilution. Despite impairment of sodium and water reabsorption, none of these patients, nor 20 additional patients, had a significant postobstructive diuresis from the previously obstructed kidney. All of the patients had normal total renal function. Thus, the changes observed were a result of the obstructive injury and were not related to azotemia or aberrations in water or sodium metabolism.


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