Effect of diphosphonate on crystallization of calcium oxalate in vitro

Pak, Charles Y. C.; Ohata, Masahiro; Holt, Karen
January 1975
Kidney International;Jan1975, Vol. 7 Issue 1, p154
Academic Journal
Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53 × 10-9 M², and was independent of duration of incubation, solid-to-solution ratio, pH, calcium concentration or ionic strength. These techniques were utilized to assess the effect of disodium ethane-1-hydroxy-l,1-diphosphonate (EHDP) on crystallization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.


Related Articles

  • Modulation of calcium oxalate monohydrate crystallization kinetics in vitro. Kok, Dik J.; Papapoulos, Socrates E.; Blomen, Leo J. M. J.; Bijvoet, Olav L. M. // Kidney International;Sep1988, Vol. 34 Issue 3, p346 

    The effects of several low and high molecular weight (mol wt) compounds on the kinetics of calcium oxalate crystallization were examined using a seeded crystal growth method in which the solubility, the growth and the agglomeration of calcium oxalate crystals were measured as three separate and...

  • Effects of trace metals on the inhibition of calcium oxalate crystallization. Mu�oz, J.; Valiente, M. // Urological Research;Aug2005, Vol. 33 Issue 4, p267 

    The aim of this study was to examine the possible effects of some trace metals on the inhibition of calcium oxalate crystallization. A test of urinary lithogenic risk was used to follow the crystallization of calcium oxalate from artificial urine in the presence of several metal ions assayed in...

  • Factors affecting calcium oxalate dihydrate fragmented calculi regrowth. Costa-Bauzá, A.; Perelló, J.; Isern, B.; Sanchis, P.; Grases, F. // BMC Urology;2006, Vol. 6, p16 

    Background: The use of extracorporeal shock wave lithotripsy (ESWL) to treat calcium oxalate dihydrate (COD) renal calculi gives excellent fragmentation results. However, the retention of post-ESWL fragments within the kidney remains an important health problem. This study examined the effect of...

  • Application of a fuzzy algorithm for pH control in a struvite crystallisation reactor. Chanona, J.; Pastor, L.; Borrás, L.; Seco, A. // Water Science & Technology;2006, Vol. 53 Issue 12, p161 

    A struvite crystallisation process is highly dependent on pH. To achieve a high phosphorus recovery as struvite it is important to have an accurate control of pH in the reactor. The high non-linear response of pH value makes manual pH control difficult. Therefore, a software based on fuzzy logic...

  • A novel process for organic acids and nutrient recovery from municipal wastewater sludge. Ahn, Y.-H.; Speece, R. E. // Water Science & Technology;2006, Vol. 53 Issue 12, p101 

    In this paper, a novel process for organic acids and nutrient recovery from municipal sludge was introduced and evaluated based on laboratory-scale studies. An economical estimation for its practical application was also performed by mass balance in a full-scale plant (Q = 158,000 m³d-1)....

  • Predicting the structure of screw dislocations in nanoporous materials. Walker, Andrew M.; Slater, Ben; Gale, Julian D.; Wright, Kate // Nature Materials;Oct2004, Vol. 3 Issue 10, p715 

    Extended microscale crystal defects, including dislocations and stacking faults, can radically alter the properties of technologically important materials. Determining the atomic structure and the influence of defects on properties remains a major experimental and computational challenge. Using...

  • Simulating micrometre-scale crystal growth from solution. Piana, Stefano; Reyhani, Manijeh; Gale, Julian D. // Nature;11/3/2005, Vol. 438 Issue 7064, p70 

    Understanding crystal growth is essential for controlling the crystallization used in industrial separation and purification processes. Because solids interact through their surfaces, crystal shape can influence both chemical and physical properties. The thermodynamic morphology can readily be...

  • Crystallization of Ba3Fe2Ge4O14 and Ba2Fe2GeO7 in Oxide—Fluoride Fluxes. Gudim, I. A.; Bezmaternykh, L. N.; Bovina, A. F. // Crystallography Reports;Dec2005, Vol. 50 Issue 7, pS106 

    Crystallization of trigonal Ba3Fe2Ge4O14 and tetragonal Ba2Fe2GeO7 barium ferrogermanates is investigated in their own fluxes diluted by B2O3–BaF2 and B2O3–PbF2 mixtures, respectively. The ratios of the components at which the properties of the fluxes satisfy the requirements for...

  • Prediction of absolute crystal-nucleation rate in hard-sphere colloids. Auer, Stefan; Frenkel, Daan // Nature;2/22/2001, Vol. 409 Issue 6823, p1020 

    Describes an experimental approach to the prediction of crystal nucleation, using a simulation of the nucleation process in a suspension of hard colloidal spheres to obtain quantitative numerical predictions of the crystal nucleation rate. Factors which limit the application of classical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics