TITLE

Focal glomerular sclerosis in nephrotic patients: An electron microscopic study of glomerular podocytes

AUTHOR(S)
Grishman, Edith; Churg, Jacob
PUB. DATE
January 1975
SOURCE
Kidney International;Jan1975, Vol. 7 Issue 1, p111
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Renal biopsy specimens of 16 adult patients with nephrotic syndrome and focal glomerular sclerosis were examined by light and electron microscopy. Particular attention was paid to alterations of podocytes. Except for loss of foot processes, five patients had no podocyte changes, five had mild changes and six had severe changes. Of the last group (group III), four patients were heroin addicts, the fifth had infectious mononucleosis and the sixth, an apparent idiopathic disease; five patients were males, 16 to 25 yr old. Podocyte changes consisted of cytoplasmic degeneration, detachment of epithelial cells from basement membranes, with filling of resulting space by cell debris and new membranes. Underlying capillaries were often collapsed. Repeat biopsies in three patients in group III revealed progression of lesions, paralleling rapid clinical deterioration. It is concluded that some cases of focal glomerular sclerosis are associated with severe damage to podocytes which may be caused by drugs, infection or unknown factors and may contribute to the development and progression of the glomerular lesions.
ACCESSION #
17965679

 

Related Articles

  • Systemic Epstein-Barr virus infection associated with membranous nephropathy in children. Araya, C. E.; González-Peralta, R. P.; Skoda-Smith, S.; Dharnidharka, V. R. // Clinical Nephrology;2006, Vol. 65 Issue 3, p160 

    Epstein-Barr virus (EBV) infection can cause diverse renal manifestations ranging from microscopic hematuria to acute renal failure. Membranous nephropathy (MN) is an uncommon and usually secondary cause of nephrotic syndrome in children, and has been reported after chronic infections and...

  • Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. Mundel, Peter; Reiser, Jochen; Oh, Jun // Pediatric Nephrology;Feb2004, Vol. 19 Issue 2, p130 

    The visceral glomerular epithelial cell, also known as the podocyte, plays an important role in the maintenance of renal glomerular function. This cell type is highly specialized and its foot processes together with the interposed slit diaphragm (SD) form the final barrier to urinary protein...

  • New insights into the pathogenesis of membranous nephropathy. Shankland, Stuart J. // Kidney International;Mar2000, Vol. 57 Issue 3, p1204 

    Editorial. Discusses the pathogenesis of membranous neuropathy causing nephrotic syndrome in adults. Target of the injury on epithelial cells; Identification of the antigens causing membranous lesions; Delineation on the mechanisms underlying the response of podocyte on the induced podocyte...

  • Pathologic Quiz Case An Unsuspected Cause of Nephrotic Syndrome. Thamboo, Thomas Paulraj; Sivaraman, Pary; Chan, Norman Hock-Ling // Archives of Pathology & Laboratory Medicine;May2004, Vol. 128 Issue 5, p593 

    The article discusses about the case of a 30 year old woman who was diagnosed with nephrotic syndrome when she was 4 years old. She was treated with steroids and was determined to be steroid-dependent. Subsequent trials of cyclosporin and cyclophosphamide failed to improve her condition and she...

  • Epstein–Barr virus-associated nephrotic syndrome. Mikhalkova, Deana; Khanna, Sahil; Vaidya, Rakhee; Sethi, Sanjeev; Hogan, Marie C. // Clinical Kidney Journal;Jan2012, Vol. 5 Issue 1, p50 

    Acute infection with Epstein–Barr virus (EBV) causes fever, fatigue and pharyngitis. Renal involvement in systemic EBV infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. Rarely, EBV infection causes nephrotic syndrome due to minimal change disease. A...

  • Three-dimensional morphometric analysis of segmental glomerulosclerosis in the rat. Remuzzi, Andrea; Pergolizzi, Rossana; Mauer, Michael S.; Bertani, Tullio // Kidney International;Nov1990, Vol. 38 Issue 5, p851 

    In idiopathic nephrotic syndrome, and in experimental models of nephrosis, changes of visceral epithelial cells involve the entire glomerular population while segmental sclerotic changes are reported to affect only a certain number of glomeruli. Because conventional determination of the...

  • Mathematical modelling the age dependence of Epstein—Barr virus associated infectious mononucleosis. Huynh, Giao T.; Adler, Frederick R. // Mathematical Medicine & Biology: A Journal of the IMA;Sep2012, Vol. 29 Issue 3, p245 

    Most people get Epstein–Barr virus (EBV) infection at young age and are asymptomatic. Primary EBV infection in adolescents and young adults, however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue and sore throat that can persist for months. Expansion...

  • Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells. RONG LI; YINHAI ZHAO; JIN CHEN; SONGJUN SHAO; XIUJUAN ZHANG // Molecular Medicine Reports;2014, Vol. 9 Issue 2, p413 

    Fisetin (3,3',4',7-tetrahydroxyflavone) has been reported to possess certain anticancer properties. It may inhibit tumor cell proliferation, metastasis and induce apoptosis. However, the effects of fisetin in preventing the metastasis of nasopharyngeal carcinoma (NPC) cells remain to be...

  • Persistence and Transition of Epstein-Barr Virus Genotypes in the Pathogenesis of Oral Hairy Leukoplakia.  // Journal of Infectious Diseases;7/15/2004, Vol. 190 Issue 2, p387 

    The article discusses the persistence and transition of Epstein-Barr virus genotypes in human immunodeficiency virus (HIV)–seropositive subjects in the pathogenesis of oral hairy leukoplakia. Topics discussed include the valacyclovir treatment, tongue epithelial tissues, infectious...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics