Short term changes in lung function, leukocytosis in blood, and lachrymal fluid among bacterial single cell protein workers after an episode with high exposure to endotoxins

Skogstad, M.; Eduard, W.; Holme, J.; Qvenild, T.; Einarsdottir, E.
August 2005
Occupational & Environmental Medicine;Aug2005, Vol. 62 Issue 8, p576
Academic Journal
Aims: To study possible effects of endotoxin exposure among bacterial single cell protein workers on pulmonary function, blood parameters, and lachrymal fluid before and after a work shift. Methods: The study included 23 men and five women who were examined at the start and at the end of a work shift. Most workers performed a task with unusually high exposure levels. Twelve of the workers were re-examined the day after. The workers were divided into three exposure groups: production workers with the highest assumed exposure levels (n = 18), engineers (n = 5), and clerks (n = 2). The median endotoxin level during a work shift was 34000 EU/m³ in the high exposure group (range 3300-89000 EU/m³), 11000 EU/m³ (range 350-27000 EU/m³) among the engineers, and 180 EU/m³ (range 60-300 EU/m³) for the clerks. The workers answered a questionnaire about work related symptoms. Assessment of lung function included dynamic lung volumes and flows. The blood analysis included cell count of leukocytes and mediators of inflammation, fibrinogen, interleukin-6 (IL-6), D-dimer, and C-reactive protein (CRP). Cells in lachrymal fluid were counted with a microscope. Results: The forced vital capacity (FVC) changed significantly (p<0.05) from 5.34 l (SD 0.9) to 5.25 l (SD 0.9) and forced expired volume in one second (FEV1) from 4.15 l (SD 0.7) to 4.07 l (SD 0.7) during the work shift. The leukocytes increased significantly (p<0.05) from 6.9 109/l (SD 1.2) to 7.7 109/l (SD 1.5) and IL-6 from 1.5 ng/l (SD 0.6) to 3.31 ng/l (SD 2.7). Except for fibrinogen, which had a borderline increase and PEF that decreased, the parameters were normalised the day after. Four of the workers had an increase of neutrofile granulocytes in the lachrymal fluid during the shift. There was a significant association between the endotoxin concentration and decrease of FEV1 despite the use of powered respirators. Conclusions: During a work shift with unusual high levels of endotoxins at a plant manufacturing bacterial single cell protein the results show that FVC and FEV1 were reduced. Mediators of inflammation increased along with leucocytosis in blood and lachrymal fluid among the workers.


Related Articles

  • Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein. Pavcnik-Arnol, Maja; Hojker, Sergej; Derganc, Metka // Intensive Care Medicine;Jul2004, Vol. 30 Issue 7, p1454 

    Objective: To evaluate markers of infection in critically ill neonates and children, comparing lipopolysaccharide-binding protein (LBP) with procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP).Design and Setting: Prospective, observational study in...

  • Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype. Agustí, Alvar; Edwards, Lisa D.; Rennard, Stephen I.; MacNee, William; Tal-Singer, Ruth; Miller, Bruce E.; Vestbo, Jørgen; Lomas, David A.; Calverley, Peter M. A.; Wouters, Emiel; Crim, Courtney; Yates, Julie C.; Silverman, Edwin K.; Coxson, Harvey O.; Bakke, Per; Mayer, Ruth J.; Celli, Bartolome // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in...

  • C-Reactive Protein, Interleukin 6 and Lung Cancer Risk: A Meta-Analysis. Bo Zhou; Jing Liu; Ze-Mu Wang; Tao Xi; Ljubimov, Alexander V. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Purpose: Epidemiologic findings are inconsistent concerning the associations between C-reactive protein (CRP), interleukin 6 (IL-6) and lung cancer risk. We conducted a meta-analysis of epidemiologic studies to examine these associations. Methods: A systematic literature search up to October...

  • Fluticasone Appears to Reduce Lung-Specific Inflammation.  // Pulmonary Reviews;Jun2008, Vol. 13 Issue 6, p20 

    The article discusses research being done on the effect of fluticasone on lung-specific inflammation. It references a study by Don D. Sin et al in the June 1, 2008 issue of the "American Journal of Respiratory and Critical Care Medicine." The researchers observed patients with a clinical...

  • High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study. Pavare, Jana; Grope, Ilze; Kalnins, Imants; Gardovska, Dace // BMC Infectious Diseases;2010, Vol. 10 Issue 1, p28 

    Introduction: Even though sepsis is one of the common causes of children morbidity and mortality, specific inflammatory markers for identifying sepsis are less studied in children. The main aim of this study was to compare the levels of high-mobility group box-1 protein (HMGB1),...

  • Interleukin-6 and statin therapy: potential role in the management of COPD. Young, Robert P.; Hopkins, Raewyn J. // Respiratory Research;Jul2013, Vol. 14 Issue 7, p1 

    A letter to the editor is presented in response to the article "Three-year follow-up of interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease," by R. Ferrari and colleagues in the 2013 issue.

  • Serum concentrations of interleukin-6 in patients following unilateral versus bilateral total knee arthroplasty. Hajime Kugisaki; Motoki Sonohata; Mitsunori Komine; Kenji Tsunoda; Shinsuke Someya; Hidefumi Honke; Masaaki Mawatari; Takao Hotokebuchi // Journal of Orthopaedic Science;Jul2009, Vol. 14 Issue 4, p437 

    Abstract Background  Surgical stress is known to affect body temperature, white blood cell (WBC) count, C-reactive protein (CRP), and interleukin-6 (IL-6). The aim of the present study was to investigate which parameter is most suitable for quantitative analysis of surgical stress. ...

  • Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease. Ferrari, Renata; Tanni, Suzana E.; Caram, Laura M. O.; Corrêa, Corina; Corrêa, Camila R.; Godoy, Irma // Respiratory Research;Feb2013, Vol. 14 Issue 2, p1 

    Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and...

  • Heterogeneity of Altered Cytokine Levels Across the Clinical Spectrum of Diabetes in China. YUFEI XIANG; PENGCHENG ZHOU; XIAOJUE LI; GAN HUANG; ZHENQI LIU; AIMIN XU; LESLIE, R. DAVID; ZHIGUANG ZHOU // Diabetes Care;Jul2011, Vol. 34 Issue 7, p1639 

    OBJECTIVE--To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS--Adult patients with recent-onset type 1 diabetes (n = 53), latent autoimmune diabetes in adults (LADA) (n = 250), and type 2 diabetes (n = 285) from multiple centers...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics