Investigating time patterns of variation in radiation cancer associations

Richardson, D. B.; Ashmore, J. P.
August 2005
Occupational & Environmental Medicine;Aug2005, Vol. 62 Issue 8, p551
Academic Journal
Aims: In occupational settings, carcinogenic exposures are often repeated or protracted over time. The time pattern of exposure accrual may influence subsequent temporal patterns of cancer risk. The authors present several simple models that may be used to evaluate the influence of time since exposure or age at exposure on cancer incidence or mortality in an occupational cohort. Methods: A cohort of 40 415 nuclear industry workers was identified via the Canadian National Dose Registry. Vital status and cause of death were ascertained through 1994. Associations between ionising radiation and mortality due to lung cancer, leukaemia, and cancers other than lung and leukaemia were quantified using conditional logistic regression models with risk sets constructed by incidence density sampling. A step function, a bilinear function, and a sigmoid function were used to evaluate temporal variation in exposure effects. Results: Step and sigmoid functions were used to explore latency and morbidity periods. For analyses of lung cancer, leukaemia, and other cancers the best fitting models were obtained when exposure assignment was lagged by 13, 0, and 5 years, respectively. A bilinear function was used to evaluate whether exposure effects diminished with time since exposure. In analyses of lung cancer and leukaemia, there was evidence that radiation effects attenuated with protracted time since exposure. In analyses of age at exposure, there was evidence of variation in radiation mortality associations for analyses of lung cancer and leukaemia; discounting radiation doses accrued at younger ages (for example, 15-35 years) led to significant improvements in model fit. Conclusions: This paper illustrates empirical approaches to evaluating temporal variation in the effect of a protracted exposure on disease risk.


Related Articles

  • Environmental risk factors for lung cancer in Iran: a case–control study. Hosseini, Mostafa; Naghan, Parisa Adimi; Karimi, Shirin; SeyedAlinaghi, SeyedAhmad; Bahadori, Moslem; Khodadad, Kian; Mohammadi, Forouzan; Kaynama, Kaveh; Masjedi, Mohammad Reza // International Journal of Epidemiology;Oct2010, Vol. 39 Issue 5, p1405 

    A correction to the article "Environmental Risk Factors for Lung Cancer in Iran: A Case-Control Study," by Mostafa Hosseini and colleagues is presented.

  • Risk of Cancer in relation to Natural Radiation, including Radon: Evidence from Epidemiological Studies. Baysson, Hélène; Tirmarche, Margot; Laurier, Dominique // AIP Conference Proceedings;8/7/2008, Vol. 1034 Issue 1, p43 

    A review of recently published epidemiological studies on populations exposed to natural background ionizing radiation is proposed. The advantages and disadvantages of different types of epidemiological studies as well as the uncertainty linked to multiple exposures are discussed. As radon is...

  • Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France.  // BMC Public Health;2011, Vol. 11 Issue 1, p928 

    The article focuses on a study that explores occupational risk factors for lung, head and neck cancers. It discusses case control study ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers), which investigates occupational risk factors for lung and head and neck...

  • Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposure. Vocht, Frank; Burstyn, Igor; Ferro, Gilles; Olsson, Ann; Hashibe, Mia; Kromhout, Hans; Boffetta, Paolo // International Archives of Occupational & Environmental Health;May2009, Vol. 82 Issue 6, p723 

    A multi-centre IARC-coordinated European cohort study provided evidence of an association between lung cancer risk and bitumen fume exposure. Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not...

  • Screening for lung cancer. Grant, Ian W.B. // British Medical Journal (Clinical Research Edition);4/24/1982, Vol. 284 Issue 6324, p1209 

    Focuses on the screening for lung cancer. Causes on the development of lung cancer; Contribution of diagnosis to survival from lung cancer; Benefits from early diagnosis of the malignant disease.

  • Mortality in a cohort of Staffordshire pottery workers: follow-up to December 2008. Harris, Jessica; McDonald, Corbett; Turner, Susan; Taylor, Tony Newman; Cullinan, Paul; Cherry, Nicola // Occupational & Environmental Medicine;Mar2013, Vol. 70 Issue 3, p149 

    Objectives To examine mortality from lung cancer, chronic obstructive pulmonary disease (COPD) and chronic non-malignant renal disease (cNMRD) in pottery workers exposed to silica. Methods A cohort of Stoke-on-Trent pottery workers (N=5115), previously followed to 1992, was traced for vital...

  • Lung cancer a prescribed industrial disease.  // Accountancy;Apr87, Vol. 99 Issue 1124, p53 

    Announces the addition of lung cancer to the list of prescribed industrial diseases under regulations which took effect on April 1, 1987. Eligibility of employees to payments under the Industrial Injuries Benefit Scheme.

  • Lung cancer a prescribed industrial disease.  // Accountancy;Apr87, Vol. 99 Issue 1124, p53 

    Announces the addition of lung cancer to the list of prescribed industrial diseases under regulations which took effect on April 1, 1987. Eligibility of employees to payments under the Industrial Injuries Benefit Scheme.

  • Occupational exposure to lead and lung cancer: results from two case-control studies in Montreal, Canada. Wynant, Willy; Siemiatycki, Jack; Parent, Marie-Élise; Rousseau, Marie-Claude // Occupational & Environmental Medicine;Mar2013, Vol. 70 Issue 3, p164 

    Objectives We investigated the association between workplace lead exposure and lung cancer risk, separately for organic lead and for inorganic lead, from either engine emissions or from other sources. Methods Two population-based case-control studies were carried out in Montreal (1979-1986 and...


Read the Article


Sign out of this library

Other Topics