Tips for learners of evidence-based medicine: 5. The effect of spectrum of disease on the performance of diagnostic tests

Montori, Victor M.; Wyer, Peter; Newman, Thomas B.; Keitz, Sheri; Guyatt, Gordon
August 2005
CMAJ: Canadian Medical Association Journal;8/16/2005, Vol. 173 Issue 4, p385
Academic Journal
Presents a series of examples that illustrate why clinicians need to pay close attention to the populations enrolled in studies of diagnostic test performance before they apply the results of those studies to their own patients. Characteristics of the right population for a diagnostic test study; Reason for the variation of test performance with the spectrum of disease within a study population; Effects of spectrum of disease and disease prevalence on diagnostic test characteristics.


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