TITLE

Gastric Adenocarcinoma Associated With Fundic Gland Polyps in a Patient With Attenuated Familial Adenomatous Polyposis

AUTHOR(S)
Hofgärtner, Wolfgang T.; Thorp, Micah; Ramus, Mark W.; Delorefice, Guy; Chey, William Y.; Ryan, Charlotte K.; Takahashi, Garry W.; Lobitz, John R.
PUB. DATE
August 1999
SOURCE
American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2275
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Familial adenomatous polyposis (FAP) is a rare autosomal dominant precancerous condition of the colon caused by mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. FAP is characterized by the appearance of innumerable adenomatous polyps throughout the large bowel. Fundic gland polyps are the most common gastric lesion in FAP. It is generally believed that fundic gland polyps have little or no potential for malignant transformation in the population at large, and only a few ease reports describe the development of high grade dysplasia or gastric adenocarcinoma associated with diffuse fundic gland polyposis in patients with FAP. We report the second ease of gastric adenocarcinoma intimately associated with fundic gland polyposis in a family with an attenuated form of FAP. The patient had undergone routine screening per current guidelines because of his known mutation in the APC gene. This suggests that malignant transformation of fundic gland polyps in patients with FAP occur more frequently than previously believed. Current sereening recommendations may not be sufficient for patients with FAP or its attenuated forms.
ACCESSION #
17831004

 

Related Articles

  • Gastric Dysplasia and Gastric Cancer: Helicobacter pylori, Serum Vitamin C, and Other Risk Factors. Wei-cheng You; Lian Zhang // JNCI: Journal of the National Cancer Institute;10/04/2000, Vol. 92 Issue 19, p1607 

    Reports on the factors which contribute to the progression of precancerous lesions to gastric cancer among adults in Linqu County, China. Odds ratio for progression to dysplasia and gastric cancer; Baseline levels of serum nutrient concentrations.

  • Hallazgos histopatológicos y expresión de p53 y Ki67 en queilitis actínica. Mercadillo-Pérez, Patricia; Moreno-López, Luis Miguel // Revista Medica del Hospital General de Mexico;abr-jun2012, Vol. 75 Issue 2, p90 

    Introduction: Actinic cheilitis is the most common premalignant lesion of the lip, and it is frequently located on the lower lip. In premalignant and malignant oral lesions, p53 mutations have been reported in a very high frequency, and it has been shown that the Ki67 expression has a role in...

  • Gastric Adenocarcinoma Arising from Fundic Gland Polyps in a Patient with Familial Adenomatous Polyposis Syndrome. Garrean, Sean; Hering, Justin; Saied, Abdul; Jani, Jigna; Espat, Joseph // American Surgeon;Jan2008, Vol. 74 Issue 1, p79 

    Familial adenomatous polyposis (FAP) is a rare hereditary syndrome characterized by multiple colorectal polyps and early development of colorectal cancer. Although FAP uniformly involves the large bowel, it may also produce lesions in the stomach and upper intestinal tract. Fundic gland polyps...

  • ATROPHIC GASTRITIS, INTESTINAL METAPLASIA AND GASTRIC DYSPLASIA. Onisor, Danusia Maria; Dobru, Daniela; Boeriu, Alina; Pascarenco, Ofelia; Brusnic, Olga; Stoian, Adina; Stoian, M.; Cozma, D. // Acta Medica Transilvanica;jun2012, Vol. 17 Issue 2, p150 

    Introduction: the detection of gastric preneoplastic lesions (atrophic gastritis, intestinal metaplasia, dysplasia) is important regarding the patient's risk evaluation for gastric cancer. The purpose of this study consists in the pit pattern evaluation, specific to the 3 premalignant lesions by...

  • Image-Guided Raman Spectroscopy For In Vivo Diagnosis of Gastric Precancer At Gastroscopy. Huang, Zhiwei; Bergholt, Mads Sylvest; Zheng, Wei; Lin, Kan; Ho, Khek Yu; Teh, Ming; Yeoh, Khay Guan // AIP Conference Proceedings;8/6/2010, Vol. 1267 Issue 1, p438 

    We report on the implementation of a narrow-band image (NBI)-guided Raman endoscopy for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric tissue within 0.5 second at gastroscopy. Significant Raman spectral differences...

  • ENDOSCOPIA CU MAGNIFICAÅ¢IE ÅŸI CROMOENDOSCOPIA ÃŽN GASTRITA ATROFICÄ‚, METAPLAZIA INTESTINALÄ‚ ÅžI DISPLAZIA GASTRICÄ‚. Maria, Onişor Danusia; Daniela, Dobru; Alina, Boeriu; Ofelia, Pascarenco; Olga, Brusnic; Adina, Stoian; Mircea, Stoian; Dan, Cozma // Acta Medica Transilvanica;jun2012, Vol. 17 Issue 2, p32 

    Introduction: the detection of gastric preneoplastic lesions (atrophic gastritis, intestinal metaplasia, dysplasia) is important regarding the patient's risk evaluation for gastric cancer. The purpose of this study consists in the pit pattern evaluation, specific to the 3 premalignant lesions by...

  • PTEN EXPRESSION PROFILES IN COLORECTAL ADENOCARCINOMA AND ITS PRECANCEROUS LESIONS. WANICZEK, DARIUSZ; ŚNIETURA, MIROSŁAW; MŁYNARCZYK-LISZKA, JOANNA; PIGŁOWSKI, WOJCIECH; KOPEĆ, AGNIESZKA; LANGE, DARIUSZ; RUDZKI, MAREK; ARENDT, JERZY // Polish Journal of Pathology: Official Journal of the Polish Soci;2013, Issue 1, p15 

    The aim of the study was to determine expression of the PTEN suppressor gene in colorectal adenocarcinoma and its precancerous lesions (adenomatous polyps) in correlation with common clinical and histopathological features. Forty-four patients with adenomatous polyps and 32 with primary...

  • PANEL DISCUSSION ON LATEST DEVELOPMENTS IN CANCER OF THE GASTROINTESTINAL TRACT.  // American Journal of Gastroenterology;Jul1954, Vol. 22 Issue 1, p9 

    Presents a panel discussion on developments in cancer of the gastrointestinal tract presented before the 18th Annual Convention of the National Gastroenterological Association in Los Angeles, California from October 12 to 14, 1953. Use of an x-ray examination of a patient suspected of having...

  • Synchronous carcinomatous lesions in the stomach. Arcot, Rekha; Annamalai, Ravi; Sundaram, Sandhya; Kuruvillah, Sarah // Indian Journal of Surgery;Oct2006, Vol. 68 Issue 5, p278 

    The article presents information on synchronous gastric cancers. In case of a patient in whom the gastric adenocarcinoma has been diagnosed in endoscopy, due to the presence of ulcerated lesions in his stomach, it can be the case of multiple synchronous gastric cancers if the histopathological...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics