Predominant Symptoms Identify Different Subgroups in Functional Dyspepsia

Stanghellini, Vincenzo; Tosetti, Cesare; Paternicò, Anna; De Giorgio, Roberto; Barbara, Giovanni; Salvioli, Beatrice; Corinaldesi, Roberto
August 1999
American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2080
Academic Journal
OBJECTIVE: Dyspepsia is a common syndrome that often defies diagnosis. Whether the unexplained (or "functional") dyspepsia represents a homogeneous syndrome or includes different subgroups with specific clinical features has not been clarified. The aim of this study was to investigate the relationship between symptom severity, demographic features, and gastric dysmotility in a large series of patients with functional dyspepsia. METHODS: Severity of individual digestive symptoms, demographic features, and scintigraphic gastric emptying of solids were evaluated in 483 patients with chronic unexplained dyspepsia. RESULTS: Two main subgroups were identified. The first was characterized by predominant epigastric pain, male gender (61%), and normal gastric emptying. The second subgroup was characterized by predominant nonpainful symptoms, female gender (60%), a high frequency of associated irritable bowel syndrome (30%), and delayed gastric emptying (42%). A third group included approximately one-third of patients who did not present with any predominant symptom, and was characterized by a high frequency of delayed gastric emptying (30%), overlapping irritable bowel syndrome (28%), and gastroesophageal reflux disease (41%). CONCLUSIONS: Different subgroups exist among patients with functional dyspepsia seen in a referral center. They can be identified by the predominant symptom and are characterized by different demographic, clinical, and pathophysiological features.


Related Articles

  • Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia. Seiji Futagami; Hiroshi Yamawaki; Mayumi Shimpuku; Nikki Izumi; Taiga Wakabayashi; Yasuhiro Kodaka; Hiroyuki Nagoya; Tomotaka Shindo; Tetsuro Kawagoe; Choitsu Sakamoto // Journal of Nippon Medical School;2013, Vol. 80 Issue 5, p362 

    Background/Aims: The association between clinical symptoms and sleep disorders in functional dyspepsia (FD)-overlap syndrome has not been studied in detail. Methods: The subjects were 139 patients with FD, 14 with irritable bowel syndrome (IBS), 12 with nonerosive reflux disease (NERD), and 41...

  • Functional Dyspepsia in Review: Pathophysiology and Challenges in the Diagnosis and Management due to Coexisting Gastroesophageal Reflux Disease and Irritable Bowel Syndrome. Yarandi, Shadi S.; Christie, Jennifer // Gastroenterology Research & Practice;2013, p1 

    Functional dyspepsia is a common disorder which imposes significant diagnostic and treatment challenges for patients and physicians. The most recent update of the diagnostic criteria subdivides functional dyspepsia into two subcategories based on the main symptom of epigastric pain or postmeal...

  • Functional dyspepsia: past, present, and future. Geeraerts, Brecht; Tack, Jan // Journal of Gastroenterology;2008, Vol. 43 Issue 4, p251 

    Functional dyspepsia (FD) is a highly prevalent gastrointestinal disorder characterized by symptoms originating from the gastroduodenal region in the absence of underlying organic disease that readily explains the symptoms. The Rome II consensus, which defined FD as the presence of unexplained...

  • Natural History of Gastroesophageal Reflux Disease and Functional Abdominal Disorders: A Population- Based Study. Agréus, Lars; Svärdsudd, Kurt; Talley, Nicholas J.; Jones, Michael P.; Tibblin, Gösta // American Journal of Gastroenterology;Oct2001, Vol. 96 Issue 10, p2905 

    OBJECTIVE: Symptomatic gastroesophageal reflux disease (GERD), dyspepsia, and irritable bowel syndrome (IBS) are generally considered to be chronic conditions, but community- based studies are sparse, and long term natural history data are unavailable. We aimed to determine the natural history...

  • What Is the Profiles for Predicting Treatment Responsiveness in Gastroesophageal Reflux Disease? Seon Young Park // Journal of Neurogastroenterology & Motility;Jul2012, Vol. 18 Issue 3, p342 

    The article reports on the study of patients suffering from gastroesophageal reflux disease (GERD) symptoms. It mentions that several patients were examined in which some had functional digestive disorders like functional dyspepsia and irritable bowel syndrome and analysis of patients were done...

  • Sphincter central cause of GORD.  // New Zealand Doctor;8/24/2011, p40 

    The article offers information on the contribution of having a chronically weak sphincter to the development of gastro-oesophageal reflux disease (GORD). It assesses whether GORD can be caused by reflux acid or reflux volume. The author also explores the other causes of this disease such as...

  • Acupuncture for functional gastrointestinal disorders. Takahashi, Toku // Journal of Gastroenterology;May2006, Vol. 41 Issue 5, p408 

    Functional gastrointestinal (GI) symptoms are common in the general population. Especially, motor dysfunction of the GI tract and visceral hypersensitivity are important. Acupuncture has been used to treat GI symptoms in China for thousands of years. It is conceivable that acupuncture may be...

  • Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. Stanghellini, Vincenzo; Tosetti, Cesare; Barbara, Giovanni; Giorgio, Roberto De; Cogliandro, Laura; Cogliandro, Rosanna; Corinaldesi, Roberto // American Journal of Gastroenterology;Nov2002, Vol. 97 Issue 11, p2738 

    OBJECTIVES:Irritable bowel syndrome (IBS) and dyspepsia often overlap. Delayed gastric emptying has been reported in IBS patients, although conflicting results exist. Whether overlapping dyspepsia correlates with gastric emptying abnormalities in IBS patients has not been clarified. This study...

  • The Pathophysiology, Diagnosis and Treatment of Excessive Belching Symptoms. Kessing, Boudewijn F; Bredenoord, Albert J; Smout, André J P M // American Journal of Gastroenterology;Aug2014, Vol. 109 Issue 8, p1196 

    Excessive belching is a commonly observed complaint in clinical practice that can occur not only as an isolated symptom but also as a concomitant symptom in patients with gastroesophageal reflux disease (GERD) or functional dyspepsia. Impedance monitoring has revealed that there are two...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics