The Effect of Erythromycin on Gastric Emptying Is Modified by Physiological Changes in the Blood Glucose Concentration

Jones, Karen L.; Kong, Marie-France; Berry, Melanie K.; Rayner, Chris K.; Adamson, Ulf; Horowitz, Michael
August 1999
American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2074
Academic Journal
OBJECTIVE: The aim of this study was to determine whether variations in the blood glucose concentration within the normal postprandial range affect the gastrokenetic action of erythromycin. METHODS: Six healthy male volunteers, aged 20-33 yr underwent measurements of gastric emptying on 2 separate days; blood glucose concentrations were maintained at approximately 4 mmol/L (72 mg/dl) on 1 day and at 8 mmol/L (144 mg/dl) on the other. The order of the two studies was randomized and they were separated by 4-7 days. On both days, erythromycin (3 mg/kg) was administered intravenously over 15 min immediately before consumption of 300 g minced beef labeled with 20 MBq 99mTc-sulphur colloid chicken liver and 150 ml water labeled with 67Ga-EDTA. RESULTS: Gastric emptying of solid (p < 0.05) and liquid (p < 0.0001) were slower at a blood glucose concentration of 8 mmol/L (144 mg/dl) when compared to 4 mmol/L (72 mg/dl). The slowing of gastric emptying was associated with greater retention of both solid and liquid in the proximal (p < 0.06) and distal (p < 0.01) stomach. CONCLUSIONS: After administration of erythromycin, gastric emptying and intragastric distribution of solids and liquids is influenced by physiological changes in the blood glucose concentration.


Related Articles

  • The Stimulation of Antral Motility by Erythromycin Is Attenuated by Hyperglycemia. Rayner, C. K.; Su, Y.-C.; Doran, S. M.; Jones, K. L.; Malbert, C. H.; Horowitz, M. // American Journal of Gastroenterology;Sep2000, Vol. 95 Issue 9, p2233 

    OBJECTIVE: Diabetic gastroparesis is usually treated with prokinetic drugs, of which the most potent, when given intravenously during euglycemia, is erythromycin. Recent studies have demonstrated that the gastrokinetic effects of erythromycin are attenuated by hyperglycemia. The aim of this...

  • The botanical integrity of wheat products influences the gastric distention and satiety in healthy subjects. Hlebowicz, Joanna; Lindstedt, Sandra; Björgell, Ola; Höglund, Peter; Almér, Lars-Olof; Darwiche, Gassan // Nutrition Journal;2008, Vol. 7, Special section p1 

    Background: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid...

  • Exercise and Glycemic Control in Diabetes: Benefits, Challenges, and Adjustments to Pharmacotherapy. Arthur Gulve, Eric // Physical Therapy;Nov2008, Vol. 88 Issue 11, p1297 

    Exercise, along with dietary intervention, represents first-line therapy for diabetes mellitus. Aerobic exercise is recommended for its beneficial effects on glucose control as well as its abilities to retard the progression of other comorbidities common in patients with diabetes, such as...

  • Hyperglycemia Attenuates the Gastrokinetic Effect of Erythromycin and Affects the Perception of Postprandial Hunger in Normal Subjects. Jones, Karen L.; Berry, Melanie; Kong, Marie-France; Kwiatek, Monika A.; Samson, Melvin; Horowitz, Michael // Diabetes Care;Feb99, Vol. 22 Issue 2, p339 

    Presents information on a study regarding the effects of blood glucose concentration in modifying the action of erythromycin on gastric emptying, postpradial hunger and fullness. Stabilization of blood glucose concentration; Measurement of gastric emptying, fullness and hunger; Mechanism of...

  • Comparison of the Soluble Basal Insulin Analog Insulin Detemir With NPH Insulin. Hermansen, Kjeld; Madsbad, Sten; Perrild, Hans; Kristensen, Allan; Axelsen, Mads // Diabetes Care;Feb2001, Vol. 24 Issue 2, p296 

    Presents a study which compared the blood glucose-lowering effect of insulin detemir with that of NPH insulin. Information on insulin detemir; Research design and methodology; Results and conclusions.

  • Prolonged Oxidative Stress Impairs Insulin-Induced GLUT4 Translocation in 3T3-L1 Adipocytes. Rudich, Assaf; Tirosh, Amir; Potashnik, Ruth; Hemi, Rina; Kanety, Hannah; ashan, Nava B // Diabetes;Oct1998, Vol. 47 Issue 10, p1562 

    Discusses the effect of oxidative stress on insulin stimulation of glucose transport activities in the human body. Increase of plasma membrane GLUT4's content through insulin; Reduction of low-density microsomal (LDM) fraction in control cells; Impact of insulin on 2-deoxyglucose uptake activity.

  • Long-Run Protection. Stanten, Michele; Yeager, Selene // Prevention;Aug2002, Vol. 54 Issue 8, p70 

    Promotes physical exercise, even for overweight people, because it helps control blood sugar better and longer.

  • CLINICAL BRIEFS.  // New Zealand Doctor;7/3/2013, p33 

    The article presents abstracts on medical topics which include postprandial walking's role in improving the levels of blood sugar, how obstructive sleep apnoea (OSA) can increase sudden cardiac death's risk, and the need for the older patients on statins to avoid erythromycin and clarithromycin.

  • Enhancement of Intestinal Motility and Transit Time in Streptozotozin-Induced Diabetic Rats Treated with Ocimum gratissimum. Akpan, Okon Uduak; Odeh, Obembe Agona; Otu, Ita Sunday; E., Osim Eme // British Journal of Medicine & Medical Research;Oct-Dec2013, Vol. 3 Issue 4, p1835 

    Aims: Acute changes in the blood glucose concentration have a substantial effect on intestinal motility in both diabetic and healthy subjects. This research work was therefore designed to assess the effect of DM on GIT motor activity and the impact of treatment with OG on same. Methodology: The...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics