Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma
- Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Bhat, A A; Pope, J L; Smith, J J; Ahmad, R; Chen, X; Washington, M K; Beauchamp, R D; Singh, A B; Dhawan, P // Oncogene;8/27/2015, Vol. 34 Issue 35, p4570
In normal colon, claudin-7 is one of the highly expressed claudin proteins and its knockdown in mice results in altered epithelial cell homeostasis and neonatal death. Notably, dysregulation of the epithelial homeostasis potentiates oncogenic transformation and growth. However, the role of...
- Retinoblastoma -- clinical and genetic aspects: a review. Cowell, J. K.; Hungerford, J.; Jay, M.; Rutland, P. // Journal of the Royal Society of Medicine;Apr1988, Vol. 81 Issue 4, p220
The article discusses the clinical and genetic aspects of retinoblastoma, a malignant ocular tumor involving the retinal cells. Most cases of retinoblastoma are apparently sporadic, but a significant proportion are familial and inheritance follows an autosomal dominant mode with high penetrance....
- BY THE NUMBERS. // Hem/Onc Today;6/10/2012, Vol. 13 Issue 11, p1
A chart is presented that offers information on the increasing number of cardiac cases among survivors of childhood cancer who have undergone cardiotoxic therapy.
- Colorectal Cancer in Young Adults. Inra, Jennifer; Syngal, Sapna // Digestive Diseases & Sciences;Mar2015, Vol. 60 Issue 3, p722
The incidence and mortality rates of colorectal cancer (CRC) have been decreasing in adults over 50 years of age, however, these rates have been increasing in adults under 50. The majority of CRC in young adults is sporadic, and is likely due to behavioral and environmental causes, however the...
- Victory in cancer cure is not always as sweet as publicized. Coppes, Max J. // Hem/Onc Today;2/25/2014, Vol. 15 Issue 4, p30
The author offers insights on two studies which investigated ill effects of cancer in young patients, including one by Kevin R. Krull and colleagues that was published in the "Journal of Clinical Oncology," and another by Donghao Lu and colleagues that was featured in "Annals of Oncology" journal.
- Interpretation of genome-wide infinium methylation data from ligated DNA in formalinfixed, paraffin-embedded paired tumor and normal tissue. // BMC Research Notes;2012, Vol. 5 Issue 1, p117
The article presents information on a study which evaluates the accuracy of DNA methylation data obtained with a modified ligation-based DNA repair protocol by comparing paired fresh-frozen (FF) and FFPE colon tissue (normal and tumor) from colorectal cancer patients. The ligation-based DNA...
- Childhood cancer incidence and survival in Spain. Peris-Bonet, R.; Salmerón, D.; Martínez-Beneito, M. A.; Galceran, J.; Marcos-Gragera, R.; Felipe, S.; González, V.; Sánchez de Toledo Codina, J. // Annals of Oncology;May2010, Vol. 21 Issue suppl_3, piii103
Background: This article affords an overview of the patterns and time trends of childhood cancer incidence (1983â€“2002) and survival (1991â€“2002) in Spain.
- Bone-mineral density deficits from childhood cancer and its therapy: A review of at-risk patient cohorts and available imaging methods. Kaste, Sue C. // Pediatric Radiology;May2004, Vol. 34 Issue 5, p373
The growing population of childhood cancer survivorsâ€”currently estimated at 1 in 900 young adults aged 15â€“45 yearsâ€”underscores the importance of studying long-term complications of oncotherapy. While these patients are returning to the mainstream of life, they carry with...
- Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Bonate, Peter L.; Arthaud, Larry; Cantrell Jr., William R.; Stephenson, Katherine; Secrist, John A.; Weitman, Steve // Nature Reviews Drug Discovery;Oct2006, Vol. 5 Issue 10, p855
The treatment of acute leukaemias, which are the most common paediatric cancers, has improved considerably in recent decades, with complete response rates approaching âˆ¼90% in some cases. However, there remains a major need for treatments for patients who do not achieve or maintain complete...