TITLE

New IBD genes?

AUTHOR(S)
McGovern, D.; Ahmad, T.
PUB. DATE
August 2005
SOURCE
Gut;Aug2005, Vol. 54 Issue 8, p1060
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article states that new reports of potential novel inflammatory bowel disease (IBD) genes further advance one's understanding of the genetic basis of IBD. Crohn's disease and ulcerative colitis result from an inappropriate response of the mucosal immune system to the normal enteric flora in a genetically susceptible individual. Researchers V.D. Peltekova, R.F. Wintle, and L.A. Rubin suggest that true IBD disease causing mutations occur in SLC22A4 and SLC22A5 genes. These proteins are involved in the elimination of toxins and the uptake of various physiological substrates.
ACCESSION #
17813994

 

Related Articles

  • Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease. Natalia Elguezabal, Natalia Elguezabal; Susana Chamorro, Susana Chamorro; Elena Molina, Elena Molina; Joseba M Garrido, Joseba M Garrido; Ander Izeta, Ander Izeta; Luis Rodrigo, Luis Rodrigo; Ramon A Juste, Ramon A Juste // Gut Pathogens;2012, Vol. 4 Issue 1, p6 

    Background: Inflammatory Bowel Disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), is caused by a complex interplay involving genetic predisposition, environmental factors and an infectious agent. Mycobacterium avium subsp. paratuberculosis (MAP) is a promising...

  • Inflammatory bowel disease: review from the aspect of genetics. Ishihara, Shunji; Aziz, M.; Yuki, Takafumi; Kazumori, Hideaki; Kinoshita, Yoshikazu // Journal of Gastroenterology;Nov2009, Vol. 44 Issue 11, p1097 

    Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic susceptibility” is always included. Due to substantial progress in the characterization of susceptible genes that interact with environmental influences, a number of review articles offering the latest...

  • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Ogura, Yasunori; Bonen, Denise K.; Inohara, Naohiro; Nicolae, Dan L.; Chen, Felicia F.; Ramos, Richard; Britton, Heidi; Moran, Thomas; Karaliuskas, Reda; Duerr, Richard H.; Achkar, Jean-Paul; Brant, Steven R.; Bayless, Theodore M.; Kirschner, Barbara S.; Hanauer, Stephen B.; Nunez, Gabriel; Cho, Judy H. // Nature;5/31/2001, Vol. 411 Issue 6837, p603 

    Presents a study which determined the association of a frameshift mutation in NOD2 caused by a cytosine insertion with Crohn's disease. Background on the idiopathic inflammatory bowel diseases; Methods used; Findings of the study.

  • Current Biological Therapies for Inflammatory Bowel Disease. Baumgart, Daniel C.; Dignass, Axel U. // Current Pharmaceutical Design;Dec2004, Vol. 10 Issue 32, p4127 

    Current biological therapies for inflammatory bowel disease reflect the exponential advancement in understanding the human intestinal immune system and particularly the biology of intestinal inflammation over the past decade. The better understanding of the mechanisms of inflammatory bowel...

  • Not one but two inflammatory bowel disease susceptibility loci map to chromosome 16. Adeniji, Olaitan A.; Mrug, Michal M.; DiPalma, Jack A. // American Journal of Gastroenterology;Sep2002, Vol. 97 Issue 9, p2464 

    The association of NOD2 gene mutations with inflammatory bowel disease (IBD) has been reported by multiple research groups. In this high-density linkage experiment using 39 microsatellite markers, Hampe et al. observed a triple-peaked configuration of the linkage curve with peak logarithm of...

  • Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Schnitzler, Fabian; Brand, Stephan; Staudinger, Tanja; Pfennig, Simone; Hofbauer, Katrin; Seiderer, Julia; Tillack, Cornelia; Göke, Burkhard; Ochsenkühn, Thomas; Lohse, Peter // Immunogenetics;Mar2006, Vol. 58 Issue 2/3, p99 

    We performed a limited DNA sequence analysis of the CARD15 gene in 89 patients with Crohn’s disease (CD), 19 patients with ulcerative colitis (UC), and three patients with indeterminate colitis (IC), who were heterozygous carriers of one of the common CARD15 mutations [c.2104C>T...

  • CARD15 Status and Familial Predisposition for Crohn's Disease and Colonic Gene Expression. Claudio Csillag; Ole Nielsen; Rehannah Borup; Jørgen Olsen; Jacob Bjerrum; Finn Nielsen // Digestive Diseases & Sciences;Aug2007, Vol. 52 Issue 8, p1783 

    Abstract  Familial disposition and mutations in the Caspase Recruitment Domain 15 (CARD15) have been associated with an increased risk for Crohn's disease (CD). This study investigated whether these risk factors correlate with colonic gene expression profiles generated by...

  • Systems analysis of inflammatory bowel disease based on comprehensive gene information.  // BMC Medical Genetics;2012, Vol. 13 Issue 1, p25 

    The article offers information on a study conducted by the authors in which they used knowledge driven human disease network (HDN) gene and molecular database systems to analyze inflammatory bowel disease (IBD). Around 1,000 genes associated with sibling diseases were retrieved from databases....

  • Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men. Lin, Z.; Poritz, L.; Franke, A.; Li, T.Y.; Ruether, A.; Byrnes, K.A.; Wang, Y.; Gebhard, A.W.; MacNeill, C.; Thomas, N.J.; R. Wu; Schreiber, S.; Koltun, W.A. // Disease Markers;2009, Vol. 27 Issue 5, p193 

    Background: The association of DLG5 R30Q with IBD has been replicated in several populations, but is not statistically significant in others. We studied the incidence of DLG5 alleles in a population of IBD patients from Pennsylvania. Methods: DLG5 R30Q (rs1248696) and G1066G (rs1248634) were...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics