New IBD genes?

McGovern, D.; Ahmad, T.
August 2005
Gut;Aug2005, Vol. 54 Issue 8, p1060
Academic Journal
This article states that new reports of potential novel inflammatory bowel disease (IBD) genes further advance one's understanding of the genetic basis of IBD. Crohn's disease and ulcerative colitis result from an inappropriate response of the mucosal immune system to the normal enteric flora in a genetically susceptible individual. Researchers V.D. Peltekova, R.F. Wintle, and L.A. Rubin suggest that true IBD disease causing mutations occur in SLC22A4 and SLC22A5 genes. These proteins are involved in the elimination of toxins and the uptake of various physiological substrates.


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