TITLE

Immunological requirements for a subunit vaccine against tuberculosis

AUTHOR(S)
Elhay, Martin J.; Andersen, Peter
PUB. DATE
December 1997
SOURCE
Immunology & Cell Biology;Dec1997, Vol. 75 Issue 6, p595
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tuberculosis remains one of the most important threats to world health. Current vaccination and prevention strategies are inadequate and there is an urgent need for a new vaccine. The current vaccine bacille Calmette-Guerin (BCG). is unable to protect against re-activation of disease in later life and its efficacy varies tremendously in different human populations. An ideal replacement would be a non-living subunit vaccine that could impart protective efficacy greater than BCG but without its drawbacks. Before such a goal is achieved, however, there are many parameters that need to be examined in experimental systems. Such studies have revealed that apart from the selection of immunologically relevant antigens, dosage of antigen and type of adjuvant need to be chosen carefully. These parameters need to be examined in the context of the complex biology of the disease and, despite recent progress in defining host/pathogen interactions, experimental vaccines tested so far have fallen short of the protective efficacy of BCG. A coordinated approach, stimulating the various facets of cell-mediated immunity will probably be essential for development of protective immunity through subunit vaccination.
ACCESSION #
17813835

 

Related Articles

  • DNA vaccines against tuberculosis. Lowrie, Douglas B.; Silva, Cello L.; Tascon, Ricardo E. // Immunology & Cell Biology;Dec1997, Vol. 75 Issue 6, p591 

    This edited transcript of a presentation at the 'Vaccines Beyond 2000' conference describes a series of investigations by the authors throwing light on the mechanisms of protective immunity against tuberculosis in mice and raising hope for a new kind of vaccine to replace bacille...

  • Natural Variation in Immune Responses to Neonatal Mycobacterium bovis Bacillus Calmette-Guerin (BCG) Vaccination in a Cohort of Gambian Infants. Finan, Chris; Ota, Martin O. C.; Marchant, Arnaud; Newport, Melanie J. // PLoS ONE;2008, Vol. 3 Issue 10, p1 

    Background: There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective. However, BCG could remain integral to TB control programmes because neonatal BCG protects against disseminated forms of childhood TB and many new...

  • Combined DNA Vaccines Formulated in DDA Enhance Protective Immunity against Tuberculosis. Cai, H.; Tian, X.; Hu, X. D.; Zhuang, Y. H.; Zhu, Y. X. // DNA & Cell Biology;Jul2004, Vol. 23 Issue 7, p450 

    This study evaluated the adjuvant Dimethyldioctyldecyl Ammonium Bromide (DDA) effect on the protective immunity induced by a combination of plasmids containing genes encoding antigens Ag85B, MPT-83, and ESAT-6 from Mycobacterium tuberculosis. The combined DNA vaccines in DDA resulted in...

  • New TB vaccines: is there a requirement for CD8+ T cells? W. Henry Boom // Journal of Clinical Investigation;Aug2007, Vol. 117 Issue 8, p2092 

    MHC class I-restricted CD8+ T cells are necessary to mount an immune response against Mycobacterium tuberculosis. M. tuberculosis antigens can enter MHC class I cross-processing pathways through a number of different mechanisms, including via the uptake of antigen-containing apoptotic vesicles...

  • Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1–specific cellular immune responses in vivo. Jing Ye; Guang-Sheng Chen; Hong-Ping Song; Zeng-Shan Li; Ya-Yu Huang; Ping Qu; Yu-Jing Sun; Xiu-Min Zhang; Yan-Fang Sui // Cancer Immunology, Immunotherapy;Sep2004, Vol. 53 Issue 9, p825 

    The cancer-testis antigen encoded by the MAGE-1 gene is an attractive antigen in tumor immunotherapy because it can be processed as a foreign antigen by the immune system and generate tumor-specific cellular immune response in vivo. However, increase of the potency of MAGE-1 DNA vaccines is...

  • Behind The Headlines: Vaccine may offer new hope in TB. Polak, Monika // GP: General Practitioner;11/5/2004, p20 

    The article presents information on a new vaccine that might improve tuberculosis (TB) protection if used with BCG. Reports described how the experimental vaccine MVA85A had passed phase-one safety studies with flying colours. Larger trials are under way in Gambia and are generating very...

  • Is the development of a new tuberculosis vaccine possible? Kaufmann, Stefan H. E. // Nature Medicine;Sep2000, Vol. 6 Issue 9, p955 

    Examines the obstacles in addition to the insufficient federal funding that hinder the development of tuberculosis vaccine in the United States. Federal expenditure in the United States for the development of HIV/AIDS vaccine; Feasibility related to the development of tuberculosis vaccine;...

  • Role of BCG vaccination in tuberculosis control. Rao, V. G.; Gopi, P. G.; Bhat, J.; Yadav, R.; Wares, D. F. // Current Science (00113891);5/25/2009, Vol. 96 Issue 10, p1307 

    The article reports on the use of BCG Vaccination to control tuberculosis disease in India. Accordingly, tuberculosis remains the major public health problem globally specifically in children. In this regard, BCG vaccination is used to control the disease as part of the government Universal...

  • Immune Gene Networks of Mycobacterial Vaccine--Elicited Cellular Responses and Immunity. Dan Huang; Liyou Qiu; Wang, Richard; Xioamin Lai; Du, George; Seghal, Probhat; Yun Shen; Lingyun Shao; Lisa Halliday; Jeff Fortman; Ling Shen; Letvin, Norman L.; Chen, Zheng W. // Journal of Infectious Diseases;1/1/2007, Vol. 195 Issue 1, p55 

    Gene networks of protective lymphocytes after immune activation with live attenuated vaccines remain poorly characterized. Because Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine can confer protection against fatal forms of tuberculosis in humans and monkeys, we made use of macaque...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics