TITLE

Opinion: Killing time for cancer cells

AUTHOR(S)
Klein, Shoshana; McCormick, Frank; Levitzki, Alexander
PUB. DATE
July 2005
SOURCE
Nature Reviews Cancer;Jul2005, Vol. 5 Issue 7, p573
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
As the signalling pathways that control cellular proliferation and death are unravelled, a range of targets have emerged as candidates for molecular cancer therapy. For their survival, cancer cells depend on a few highly activated signalling pathways; inhibition of these pathways has a strong apoptotic effect and can lead to tumour regression. But drugs that exploit this weakness, such as imatinib, have not cured patients: withdrawal of the drug leads to disease recurrence, and sustained treatment leads to the emergence of drug-resistant clones. Can cancer be cured, or will it have to be controlled as a chronic disease?
ACCESSION #
17792472

 

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