Angiotensin II Type 1 Receptor Blocker Inhibits Pulmonary Injury

Mancini, G. B. John; Khalil, Nasreen
June 2005
Clinical & Investigative Medicine;Jun2005, Vol. 28 Issue 3, p118
Academic Journal
Purpose: Pulmonary damage and fibrosis may be the result of diverse forms of injury and there is an association between pulmonary diseases and cardiovascular events. The purpose of this study was to evaluate the effects of an angiotensin II type I receptor blocker, valsartan, on systemic, cellular, and fibrotic consequences of pulmonary injury induced by the anti-neo- plastic antibiotic, bleomycin. Methods: Sprague Dawly rats were used in the classical bleomycin model of pulmonary fibrosis. Bleomycin (I unit, n = 7) was administered intra-tracheally to induce lung injury. Valsartan (0.66 mg) was given either concomitantly (n = 9) or for two days prior to bleomycin (n = 8). A control group (n = 6) was given normal saline. Results: Valsartan-treated animals showed abrogation of weight loss, suppression of release of total and active transforming growth factor beta-I (TGF-M), and diminished connective tissue synthesis. In an explant, lung tissue culture model devoid of alveolar macrophages (saline control, n = 3; bleomycin, n = 6; bleomycin plus valsartan, n = 12), both total and active TGF-&I were suppressed in the valsartan-treat- ed cohort. Conclusions: Valsartan, known to have cardio-protec- tive properties, was shown to be protective of bleomycin -induced pulmonary injury. Thus, ARBs may be beneficial in both cardiac and pulmonary diseases.


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