TITLE

Nosocomial Antibiotic-Associated Diarrhea Associated with Enterotoxin-Producing Strains of Methicillin-Resistant Staphylococcus Aureus

AUTHOR(S)
Boyce, John M.; Havill, Nancy L.
PUB. DATE
August 2005
SOURCE
American Journal of Gastroenterology;Aug2005, Vol. 100 Issue 8, p1828
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: The aim of this study is to present new evidence that enterotoxin-producing strains of methicillin-resistant Staphylococcus aureus may cause nosocomial antibiotic-associated diarrhea. METHODS: We conducted a prospective study that utilized standard methods to exclude other bacterial, parasitic, and viral pathogens as causes of nosocomial diarrhea in patients with heavy growth of methicillin-resistant S. aureus in their stool. Staphylococcal enterotoxin assays were performed on S. aureus strains recovered from patients' stools and on stool specimens from affected patients. Retrospective cohort studies compared the severity of diarrhea in patients with methicillin-resistant S. aureus-associated diarrhea with that of patients whose stool did not contain the organism and with patients colonized or infected with enterotoxin-negative methicillin-resistant S. aureus strains. RESULTS: During an 18-month period, 11 patients had nosocomial antibiotic-associated diarrhea associated with enterotoxin-producing strains of methicillin-resistant S. aureus. Other common bacterial, parasitic, and viral pathogens were excluded. S. aureus strains from the 11 patients produced staphylococcal enterotoxin A, A and B, or D. Eighty-nine percent of patients had the same enterotoxin(s) in stool specimens as produced by the strain recovered from their stool. Case patients had a greater number of days of diarrhea than patients without methicillin-resistant S. aureus in their stool ( p < 0.001), or randomly selected patients colonized or infected with enterotoxin-negative methicillin-resistant S. aureus ( p < 0.001). CONCLUSIONS: Our findings provide evidence that enterotoxin-producing strains of methicillin-resistant S. aureus may cause nosocomial antibiotic-associated diarrhea. Greater recognition of this disease should result in more rapid and appropriate treatment of affected patients. (Am J Gastroenterol 2005;100:1828–1834)
ACCESSION #
17742888

 

Related Articles

  • Nosocomial Infections in Pediatric Population and Antibiotic Resistance of the Causative Organisms in North of Iran. Behzadnia, Salar; Davoudi, Alireza; Rezai, Mohammad Sadegh; Ahangarkani, Fatemeh // Iranian Red Crescent Medical Journal;Feb2014, Vol. 16 Issue 2, p1 

    Background: Treatment of the nosocomial infections is complicated especially in children due to an increase in the antibiotic-resistant bacteria. Objectives: The aim of this study was to survey the nosocomial infections in children and determine the antibiotic susceptibility of their causative...

  • Frequency, characteristics, and predictors of microbiologically documented nosocomial infections after cardiac surgery Michalopoulos, Argyris; Geroulanos, Stefanos; Rosmarakis, Evangelos S.; Falagas, Matthew E. // European Journal of Cardio-Thoracic Surgery;Apr2006, Vol. 29 Issue 4, p456 

    Abstract: Objective: Nosocomial infections still remain a serious problem in patients undergoing open heart surgery. The objective of this study was to evaluate frequency, characteristics, and predictors of nosocomial infections after cardiac surgery. Methods: This prospective...

  • Amputation surgery in children: an analysis of frequency and cause of early wound problems. Banza, L. N.; Mkandawire, N. C.; Harrison, W. J. // Tropical Doctor;Jul2008, Vol. 39 Issue 3, p129 

    Amputation surgery in children is a relatively uncommon procedure. The objective of our study was to determine the incidence of complications in this type of surgery as well as any related factors. The results of our retrospective study of children aged between one and 18 years, over a five-year...

  • Acridine-orange test in neonates with nosocomial pneumonia. Gülcan, Hande; Duman, Nuray; Kumral, Abdullah; Caymaz, Sibel; Gülay, Zeynep; Özkan, Hasan; Gülcan, Hande; Gülay, Zeynep; Ozkan, Hasan // Intensive Care Medicine;Apr2004, Vol. 30 Issue 4, p729 

    Looks into the diagnosis of neonatal nosocomial pneumonia. Use of acridine-orange leukocyte cytospin test for detection of intracellular organisms in exudative materials; Number of babies examined for the study; Preparation of two cytocentrifuge microscope slides.

  • CORRECTIONS.  // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2012, Vol. 97 Issue 6, pF488 

    A correction to the article "Procalcitonin in detecting neonatal nosocomialsepsis" that was published in the previous issue is presented.

  • The Impact of Antimicrobial-Resistant, Health Care-Associated Infections on Mortality in the United States. Klevens, R. Monina; Edwards, Jonathan R.; Gaynes, R. P. // Clinical Infectious Diseases;10/1/2008, Vol. 47 Issue 7, p927 

    We used data reported from US hospitals to the National Nosocomial Infection Surveillance System of the Centers for Disease Control and Prevention for 3 specific infections: Staphylococcus aureus bloodstream infections, Pseudomonas aeruginosa pneumonias, and Escherichia coli urinary tract...

  • Saving lives and the bottom line. McCaughey, Betsy // Modern Healthcare;1/30/2006, Vol. 36 Issue 5, p23 

    The article reflects on the severity of the nosocomial-infection problem in U.S. hospitals. It cites statistics on the growth of methicillin-resistant staphylococcus aureus infections from 1974-2003. It provides an overview of the steps taken by Denmark, Finland and Holland to address high...

  • Prevention of Surgical Wound Infection. Polk Jr., Hiram C. // Annals of Internal Medicine;Nov78 Part 2, Vol. 89 Issue 5, p770 

    Examines operative wound infection. Classification of operative wound infection; Discussion on the concept of operative wound infection; Patient-related determinants of infection.

  • Bacterial isolates from burn wound infections and their antibiograms: A eight-year study. Mehta, Manjula; Dutta, Priya; Gupta, Varsha // Indian Journal of Plastic Surgery;Jan-Jun2007, Vol. 40 Issue 1, p25 

    Background: Infection is an important cause of mortality in burns. Rapidly emerging nosocomial pathogens and the problem of multi-drug resistance necessitates periodic review of isolation patterns and antibiogram in the burn ward. Aim: Keeping this in mind, the present retrospective study from...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics