Cholecystectomy and the Risk of Colorectal Cancer

Theresa Shao; Yu-Xiao Yang
August 2005
American Journal of Gastroenterology;Aug2005, Vol. 100 Issue 8, p1813
Academic Journal
OBJECTIVES: Cholecystectomy has been implicated as a possible risk factor for colorectal cancer. However, the clinical evidence and the underlying mechanism for this association are still inconclusive. We conducted a population-based study to further clarify this association. METHODS: We conducted a retrospective cohort study among all patients aged 40 yr or older in the General Practice Research Database from the United Kingdom. We excluded patients with <1 yr of colorectal cancer-free database follow-up as well as those patients who developed colorectal cancer within 1 yr after their cholecystectomies. Crude and adjusted incidence rate ratios (IRRs) were determined using Poisson regression. RESULTS: The incidence rate of colorectal cancer among cholecystectomy patients (n = 55,960) was 119 (95% CI: 106–133) per 100,000 person-years, compared to 86 (95% CI: 83–90) per 100,000 person-years among patients without a cholecystectomy (n = 574,668). Among the covariates examined, only sex and age were significant confounders and were included in the adjusted analyses. The adjusted IRR of colorectal cancer associated with cholecystectomy was 1.32 (95% CI: 1.16–1.48, p < 0.001). The positive association was present for colon cancer (adjusted IRR 1.51, 95% CI: 1.30–1.74, p < 0.001), but not for rectal cancer (adjusted IRR 1.00, 95% CI: 0.85–1.17, p= 0.99). The pattern of association was similar in men versus women. A similar association with colon cancer was observed for cholelithiasis. CONCLUSIONS: Cholecystectomy is associated with a modestly increased risk of colon cancer but not for rectal cancer. Lithogenic bile could be the underlying mechanism. (Am J Gastroenterol 2005;100:1–8)


Related Articles

  • Two Case Reports of Biliary Tract Injuries during Laparoscopic Cholecystectomy. Romano, O.; Romano, C.; Cerbone, D.; Sperlongano, P.; Caserta, L.; Frega, N.; Cimmino, G.; D'Agostino, A.; Addeo, R. // ISRN Gastroenterology;2011, Special section p1 

    Background and Study Aims. Biliary tract injuries (BTI) represent the most serious and potentially life-threatening complication of cholecystectomy occurring also during laparoscopic approaches. Patients and Methods. We describe and discuss two different cases of BTI occurring during...

  • Definitive Decompression of the Biliary Tree -- Preferred Approach to Management of Choledocholithiasis and/or Associated Pathology. de Almeida, Antonia Mendes; Omar, Mussa; Gracias, Caetano Winston; dos Santos, Noel Medina // American Journal of Gastroenterology;Dec1982, Vol. 77 Issue 12, p941 

    The experience of the senior author in the management of biliary tract lithiasis and/or associated pathology is analyzed, retrospectively until 1976 and prospectively from then on, in an attempt to ascertain the most efficient manner of handling a duct requiring surgical exploration. Primary...

  • Fluorescent cholangiography in a mouse model: an innovative method for improved laparoscopic identification of the biliary anatomy. Stiles, B. M.; Adusumilli, P. S.; Bhargava, A.; Fong, Y. // Surgical Endoscopy;Aug2006, Vol. 20 Issue 8, p1291 

    Background: Real-time imaging of the biliary anatomy may facilitate safe and timely completion of laparoscopic cholecystectomy. This study sought to determine whether the unique autofluorescent properties of bile could facilitate intraoperative identification of the biliary anatomy...

  • Operative Cholangiography in Two-Port Needlescopic Cholecystectomy. Ka-Lung Fok; Chi-Ming Poon; Kin-Wan Lee; Heng-Tat Leong // Journal of Laparoendoscopic & Advanced Surgical Techniques;Jun2006, Vol. 16 Issue 3, p247 

    We report the use of operative cholangiography in two-port needlescopic (minilaparoscopic) cholecystectomy. A prospective series of 11 patients underwent two-port needlescopic cholecystectomy with operative cholangiography. In ten cases, operative cholangiography was successfully performed....

  • Introduction of a "Safety Zone" for the Safety of Laparoscopic Cholecystectomy. Taniguchi, Yushi; Ido, Kenichi; Kimura, Ken; Yoshida, Yukio; Ohtani, Masahiko; Kawamoto, Chiaki; Isoda, Norio; Suzuki, Takanori; Kumagai, Machio // American Journal of Gastroenterology;Aug1993, Vol. 88 Issue 8, p1258 

    Anatomic variations of the biliary tract were found in 18 cases of 600 patients (3.0%) undergoing laparoscopic cholecystectomy. All bile duct anomalies were confirmed preoperatively by endoscopic retrograde cholangiography. In every case, the cystic duct and cystic artery were exposed in a...

  • Risk factors for cholecystectomy in patients with gallbladder stones after endoscopic clearance of common bile duct stones. Kang-Moon Lee; Chang Nyol Paik; Woo Chul Chung; Jin Dong Kim; Cheong Rok Lee; Jin Mo Yang // Surgical Endoscopy;Aug2009, Vol. 23 Issue 8, p1713 

    Cholecystectomy usually is recommended for patients with gallbladder (GB) stones who previously underwent endoscopic removal of common bile duct (CBD) stones. However, in practice, many patients still have GB stones after improvement of their biliary symptoms. This study aimed to evaluate risk...

  • Advantages of Sphincterotomy and Nasobiliary Tube Drainage in the Treatment of Cystic Duct Stump Leak Complicating Laparoscopic Cholecystectomy. Barthel, James; Scheider, David // American Journal of Gastroenterology;Aug1995, Vol. 90 Issue 8, p1322 

    We have used sphincterotomy and nasobiliary tube drainage in preference to other forms of endoscopic therapy to manage three cases of cystic duct stump leak complicating laparoscopic cholecystectomy. The ability to monitor daily nasobiliary tube output and to perform repeat cholangiograms...

  • Partial cholecystectomy resulting in recurrent acute cholecystitis and choledocholithiasis. Sosulski, AB; Fei, JZ; DeMuro, JP // Journal of Surgical Case Reports;Sep2012, Vol. 2012 Issue 9, p17 

    Partial cholecystectomy has been documented in the literature as a safe alternative in the management of patients with acute cholecystitis when the degree of inflammation prevents a safe dissection to identify the biliary structures for complete removal of the gallbladder. Partial...

  • Watchful Waiting After Endoscopic Removal of Common Bile Duct Stones: Cheaper and Better? Fisher, Deborah A. // American Journal of Gastroenterology;Apr2006, Vol. 101 Issue 4, p753 

    Drake et al. constructed a decision model to compare, in an older population, the costs and 2-yr survival rates of elective cholecystectomy versus expectant management after endoscopic removal of common bile duct (CBD) stones. The base case analysis indicated that the expectant management...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics