TITLE

Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies

AUTHOR(S)
Castellano, Patricia; Vignaduzzo, Silvana E.; Maggio, Rubén M.; Kaufman, Teodoro S.
PUB. DATE
August 2005
SOURCE
Analytical & Bioanalytical Chemistry;Aug2005, Vol. 382 Issue 7, p1711
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.
ACCESSION #
17719885

 

Related Articles

  • ANTI-PYRETIC ACTIVITY OF METHANOLIC EXTRACT OF PICRORRHIZA KURROA ROYLE EX. BENTH. RAJANI, A.; SWATHI, M.; MADHURI, M.; ARIFA BEGUM, S. K.; VISHNU VARDHAN REDDY, M.; HEMAMALINI, K. // International Journal of Pharma & Bio Sciences;Jan-Mar2014, Vol. 5 Issue 1, p340 

    Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate and compare antipyretic activity of Picrorrhiza kurroa royle ex. Benth by using 2, 4-Dinitro...

  • Simultaneous HPLC Determination of Methocarbamol, Paracetamol and Diclofenac Sodium. Hafsa, Deshmukh; Chanda, S.; Prabhu, Pradnya J. // E-Journal of Chemistry;2011, Vol. 8 Issue 4, p1620 

    A rapid and simple high performance liquid chromatography method was developed and validated at λ=275 nm for simultaneous determination of methocarbamol, paracetamol and diclofenac sodium (lamotrigine as an internal standard) from pharmaceutical preparation. The separation was performed using...

  • Comparative Study on The Effect of Paracetamol, Diclofenac and their Combination in Post Operative Pain Relief of Cesarean Section. Taneja, Ashima; Vidhushi; Kaur, Tanudeep; Sood, Indu Veena // JK Science;Jan-Mar2015, Vol. 17 Issue 1, p30 

    To evaluate whether the post operative pain can be managed by a single agent or a combination. A prospective non randomised study of 150 patients undergoing caesarean section over 5 months were divided into three groups. Group I received paracetmol 1g i.v 6hourly, group II received Diclofenac...

  • FDA Approves Deadly Drugs, Delays Lifesaving Therapies. Faloon, William // Life Extension;2005 Collector's Edition, p45 

    Reports on the revelation of Life Extension on the toxicity of acetaminophen. Failure of the U.S. Food and Drug Administration to mandate warnings on deadly acetaminophen products; Likelihood of patients using acetaminophen to double their risk of kidney cancer; Impact of antioxidant...

  • Antiinflammatory and Analgesic Activities of Two Dicyclic Analogues of Acetaminophen and Its Regioisomer 3-Hydroxyacetanilide. Iakovou, K.; Varvaresou, A.; Bruni, G.; Massarelli, P.; Vavayannis, A.; Kazanis, M. // Pharmaceutical Chemistry Journal;May2004, Vol. 38 Issue 5, p239 

    Studies the anti-inflammatory and analgesic activities of two dicyclic analogues of acetaminophen and its regioisomer 3-hydroxyacetanilide. Association of acetaminophen with hepatotoxicity and nephrotoxicity; Gastric ulcerogenic action; Reduction in the carrageenan induced paw edema.

  • Solubility, Polymorphism, Crystallinity, and Crystal Habit of Acetaminophen and Ibuprofen. Tu Lee; Chung Shin Kuo; Ying Hsiu Chen // Pharmaceutical Technology;Oct2006, Vol. 30 Issue 10, p72 

    Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various...

  • Antworten zu Wechselwirkung von Medikamentenmit der Grunderkrankung aus PRAXIS Nr. 6.  // Praxis (16618157);4/4/2012, Vol. 101 Issue 7, p493 

    No abstract available.

  • Low Back Pain: Are We Offering Too Much? Safdieh, Joseph E. // Neurology Alert;Jan2008, Vol. 26 Issue 5, p38 

    A CUTE LOW BACK PAIN IS A COMMON CHIEF COMPLAINT in general practice as well as in neurology. Treatment guidelines for acute low back pain at this time recommend using acetaminophen and advising patients of moderate physical activity and avoidance of bed rest. Many physicians prescribe...

  • Analgesic Efficacy of Low-Dose Diclofenac Versus Paracetamol and Placebo in Postoperative Dental Pain. Kubitzek, Florian; Ziegler, Gabrielle; Gold, Morris S.; Liu, Jiun-Min-H.; Ionescu, Elisabeta // Journal of Orofacial Pain;Summer2003, Vol. 17 Issue 3, p237 

    Aims: To compare the efficacy and safety of diclofenac-K (12.5 mg) vs paracetamol (500 mg) and placebo given in a flexible dosage regimen to treat pain resulting from extraction of impacted third molar teeth. Methods: This was a 2-day, double-blind, double-dummy, randomized, parallel-group,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics