TITLE

Electroanalytical study of fluvoxamine

AUTHOR(S)
Nouws, Henri P. A.; Delerue-Matos, Cristina; Barros, Aquiles; Rodrigues, José A.; Santos-Silva, Alice
PUB. DATE
August 2005
SOURCE
Analytical & Bioanalytical Chemistry;Aug2005, Vol. 382 Issue 7, p1662
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fluvoxamine (FVX) can be reduced at a mercury-drop electrode, with a maximum peak current intensity being obtained at a potential of −0.7 V vs. Ag/AgCl, in an aqueous electrolyte solution of pH 2. The compound was determined in a pharmaceutical product and in spiked human serum by square-wave adsorptive-stripping voltammetry (SWAdSV) after accumulation at the electrode surface, under batch conditions. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine FVX in the pharmaceutical product by use of a flow-injection analysis (FIA) system with SWAdSV detection. The methods developed were validated and successfully applied to the quantification of FVX in a pharmaceutical product. Recoveries between 76 and 89% were obtained in serum analysis. The FIA–SWAdSV method enabled analysis of up to 120 samples per hour at reduced cost, implying the possibility of competing with the chromatographic methods usually used for this analysis.
ACCESSION #
17719882

 

Related Articles

  • Administration of ziprasidone for 10 days increases cocaine toxicity in mice. Heard, K.; Krier, S.; Zahniser, N. R. // Human & Experimental Toxicology;Jun2008, Vol. 27 Issue 6, p499 

    Long-term treatment with antipsychotic medications alters the regional density of several of the neurotransmitter receptors that mediate cocaine toxicity. However, the effect of either up-or down-regulation of the neurotransmitter receptors on cocaine toxicity is unknown. In this study, we...

  • Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-?B in cardiomyocytes. Liang, Yao-Jen; Lai, Ling-Ping; Wang, Bao-Wei; Juang, Shiow-Jen; Chang, Che-Ming; Leu, Jyh-Gang; Shyu, Kou-Gi // Cardiovascular Research;Nov2006, Vol. 72 Issue 2, p303 

    Abstract: Objective: Serotonin via serotonin 2B receptors (SR2BR) regulates cardiac embryonic development and adult heart functions. However, the role of SR2BR in the failing heart due to pressure overload is not well understood. Methods: Wistar rats of aortic banding and neonatal cardiomyocyte...

  • Genetic Analysis of Lrp5 Function in Osteoblast Progenitors. Yadav, Vijay K.; Arantes, Henrique Pierotti; Barros, Elizabete Ribeiro; Lazaretti-Castro, Marise; Ducy, Patricia // Calcified Tissue International;May2010, Vol. 86 Issue 5, p382 

    The low-density lipoprotein receptor-related protein (Lrp)-5 regulates osteoblast proliferation and bone formation through its expression in duodenum by modifying the gut serotonin–bone endocrine axis. However, its direct role, if any, in osteoblast progenitor cells has not been studied...

  • Mechanisms of Acute Cocaine Toxicity. Heard, Kennon; Palmer, Robert; Zahniser, Nancy R. // Open Pharmacology Journal;2008, Vol. 2, p70 

    Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporter, neurotransmitter receptor and...

  • Determination of human serum albumin using aurothiomalate as electroactive label. De la Escosura-Muñiz, Alfredo; González-García, María Begoña; Costa-García, Agustín // Analytical & Bioanalytical Chemistry;Jan2006, Vol. 384 Issue 3, p742 

    A new electroactive label has been used to monitor immunoassays in the determination of human serum albumin (HSA) using glassy-carbon electrodes as supports for the immunological reactions. The label was a gold(I) complex, sodium aurothiomalate, which was bound to rabbit IgG anti-human serum...

  • Plasma serotonin level after 1 day of fluoxetine treatment: a biological predictor for antidepressant response? Alvarez, J.-C.; Gluck, Nathalie; Fallet, Alain; Grégoire, Anne; Chevalier, Jean-Francois; Advenier, Charles; Spreux-Varoquaux, Odile // Psychopharmacology;1999, Vol. 143 Issue 1, p97 

    Abstract Rationale: Antidepressant treatments present a delayed onset of action. Objective: The present study investigated whether plasma or serum serotonin, 5-hydroxytryptamine (5-HT), could predict clinical improvement. Methods: Biological parameters were determined after a 4-week drug-free...

  • S-Mg Does Not Change Inversely to S-FFA During Acute Stress Situations. Hansen, Ole; Johansson, Bengt W. // Angiology;Nov1989, Vol. 40 Issue 11, p1011 

    The apparently divergent changes in serum magnesium (S-Mg) and serum free fatty acids (S-FFA) in stress situations associated with elevated levels of circulating adrenaline were studied experimentally in 12 healthy volunteers, who were each given three adrenaline infusions (0.05 μg/kg bw/min...

  • Spontaneous conception in a young woman who had ovarian cortical tissue cryopreserved before chemotherapy and radiotherapy for a Ewing's sarcoma of the pelvis: Case report. L.E. Bath; G. Tydeman; H.O.D. Critchley; R.A. Anderson; D.T. Baird; W.H.B. Wallace // Human Reproduction;Nov2004, Vol. 19 Issue 11, p2569 

    We report the case of a 14 year old girl who presented with a non-metastatic Ewing's sarcoma involving her superior pubic ramus. She received 14 courses of alkylating agent-based chemotherapy and direct radiation to her hemi-pelvis (55?Gy) and is alive and disease-free 8 years later. Multiple...

  • lipid-regulating drug (Major drug group).  // Royal Society of Medicine: Medicines;2002, p333 

    This article presents information on lipid-regulating drug which is the term used to describe any of a class of drugs used in clinical conditions of hyperlipidaemia, where the blood plasma contains very high levels of certain of the lipids cholesterol and/or triglycerides. Current medical...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics