Use of a stopped-flow technique for investigation and determination of thiourea and its N-methyl derivatives as inducers of the iodine—azide reaction

Kurzawa, Jan; Janowicz, Krystyna
August 2005
Analytical & Bioanalytical Chemistry;Aug2005, Vol. 382 Issue 7, p1584
Academic Journal
A stopped-flow technique has been used to investigate the behaviour of 2-thiourea, 1-methyl-2-thiourea, 1,3-dimethyl-2-thiourea, and 1,1,3,3-tetramethyl-2-thiourea in the induced iodine–azide reaction. This technique enables the progress of the reaction to be followed by monitoring the decrease in the absorbance of the iodine–starch complex at 595 nm. The effect of the concentration of the reagents on the rate of the reaction was investigated and a kinetic method for determination of the compounds is proposed. 2-Thiourea, 1-methyl-2-thiourea, and 1,3-dimethyl-2-thiourea can be determined in the range 3–75 μmol L−1 and 1,1,3,3-tetramethyl-2-thiourea in the range 2–200 μmol L−1.


Related Articles

  • Using thiourea ligand of gold-thiourea complex to facile direct synthesis of silica@gold core-shell nanostructures. Ghazitabar, Arash; Naderi, Malek; Ranjbar, Reza; Azadmehr, Amir-reza // Journal of the Iranian Chemical Society;Dec2015, Vol. 12 Issue 12, p2253 

    This study investigates a new method of silica@gold core-shell nanoparticle (SGNP) synthesis using copper anode slime as a secondary source of gold. Thiourea can form cationic complex with gold in gold extraction process of copper anode slime. Silica nanoparticles were used as cores and their...

  • Reaction of ?-bromodipnone with thiocarbamides. Potikha, L.; Kovtunenko, V. // Chemistry of Heterocyclic Compounds;Apr2007, Vol. 43 Issue 4, p521 

    The article discusses the reaction of 4-bromo-1,3-diphenyl- 2-buten-1-one (?-bromodipnone) with a-aminoazines. The reaction of ?-bromodipnone with thiourea gave rise to 2-(2-amino-4-phenyl-4,5-dihydrothazol-4-yl)-1-phenyl-1-ethanone hydrobromide. Meanwhile, the reaction of ?-bromodipnone with...

  • Sulfonylimines of Polychloroaldehydes in Reaction with Thioamides. Rosentsveig, G. N.; Aizina, Yu. A.; Rosentsveig, I. B.; Levkovskaya, G. G.; Sarapulova, G. I.; Mirskova, A. N.; Drozdova, T. I. // Russian Journal of Organic Chemistry;Apr2003, Vol. 39 Issue 4, p554 

    N-(2,2,2-Trichloroethylidene)- and N-(2-phenyl-2,2-dichloroethylidene)amides of aromatic sulfonic acids react with thioacetamide, thiourea, and N-acetylthiourea at equimolar reagents ratio to furnish N-(1-arenesulfonamido-2,2,2-trichloroethyl)- and...

  • Synthesis and crystal structure of cytisino- N-(2-hydroxyethyl)-thiocarbamide. Kulakov, I.; Nurkenov, O.; Turdybekov, D.; Ainabaev, A.; Turdybekov, K.; Gazaliev, A. // Chemistry of Natural Compounds;Jan2009, Vol. 45 Issue 1, p66 

    A thiourea derivative of the alkaloid cytisine was synthesized by reacting it with 1-propargyloxyethoxyethylisothiocyanate. It was shown that the synthesized acetal thiourea derivative underwent hydrolysis in acidic medium to cytisino- N-(2-hydroxyethyl)-thiocarbamide, the molecular structure of...

  • Environmentally safe one-pot solvent-free synthesis of 6-aryl-1,2,4,5-tetrazinane-3-thiones(ones) catalyzed by NaHSO4-SiO2. Kanagarajan, V.; Sureshkumar, P.; Thanusu, J.; Gopalakrishnan, M. // Russian Journal of Organic Chemistry;Nov2009, Vol. 45 Issue 11, p1707 

    One-pot condensation of thiourea (urea), diverse aromatic aldehydes, and ammonium acetate in the presence of repeatedly usable heterogeneous catalyst NaHSO4-SiO2 in the absence of solvent under the microwave irradiation proceeds faster and with better yields of...

  • Efficacious Preparation of Biginelli Compounds. A Comparative Study of Different Reaction Techniques. Singh, Kamaljit; Singh, Sukhdeep; Kaur, Paramjit // Letters in Organic Chemistry;Mar2006, Vol. 3 Issue 3, p201 

    A comparative study on various reaction techniques for the preparation of Biginelli compounds and a solvent-free sonication induced green approach through condensation of aldehydes, β-ketoester and urea/thiourea, catalyzed by an acid, to obtain title compounds in a synthetically useful manner...

  • Investigations on 5-(2-aryl-2-oxo-ethylidene)-1,3-dimethylbarbituric and thiobarbituric acids: reactions with thioureas and thioacetamide. Kolos, N. N.; Zamigaylo, L. L.; Musatov, V. I. // Chemistry of Heterocyclic Compounds;Aug2009, Vol. 45 Issue 8, p970 

    Derivatives of 2-amino- and 2-methylthiazole have been synthesized by the reaction of 5-(2-aryl-2-oxoethylidene)-1,3-dimethylbarbituric and thiobarbituric acids with thioureas and thioacetamide, and also by a one-pot synthesis involving thiourea (or thioacetamide), arylglyoxals,...

  • Synthesis and structure of cobalt(III) α-dimethylglyoximates containing thiourea and [ZrF6]2− anion. Malinovskii, S.; Coropceanu, É.; Bologa, O.; Rija, A.; Gdaniec, M. // Journal of Structural Chemistry;May2007, Vol. 48 Issue 3, p506 

    Two novel coordination compounds of thiourea-containing trans-octahedral trans-dioximates of trivalent cobalt [Co(DH)2(Tu)2]2[ZrF6]·H2O and [Co(NioxH)2(Tu)2]2[ZrF6]·3H2O, where DH− is the monoanion of dimethylglyoxime, NioxH− is the monoanion of 1,2-cyclohexanone dioxime, Tu is...

  • Synthesis and mutagenic activity of the hydrochlorides of S-(2-alkoxy-5-acetylbenzyl)isothioureas and 3-substituted aminomethyl-4-alkoxyacetophenones. Kaldrikyan, M.; Khekoyan, A.; Grigoryan, L.; Paronikyan, G.; Dabrinyan, G. // Pharmaceutical Chemistry Journal;Apr2008, Vol. 42 Issue 4, p165 

    The interaction of 2-alkoxy-5-acetylbenzylchlorides with thiourea and secondary amines was used to prepare the corresponding hydrochlorides of S-(2-alkoxy-5-acetylbenzyl)isothioureas and 3-substituted aminomethylacetophenones. These latter were converted into their hydrochloride salts. Compounds...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics