Blood Stem Cell Functional Analysis
Tags: GENES; HEMATOPOIETIC stem cells; ZEBRA danio; CORD blood; BONE marrow cells; HEMATOPOIESIS; MAJOR histocompatibility complex
Related Articles
- Immunity of embryonic stem cell-derived hematopoietic progenitor cells. Zavazava, Nicholas // Seminars in Immunopathology;Dec2011, Vol. 33 Issue 6, p613
A number of medical conditions including hematopoietic stem cell malignancies, immunodeficiencies, and autoimmune diseases can be treated using bone marrow cells. However, the major hindrance to the routine use of bone marrow cells is their unparalleled immunogenicity, requiring the use of harsh...
- The�definitive�(and�primitive�) guide to zebrafish hematopoiesis. Davidson, Alan J.; Zon, Leonard I. // Oncogene;9/20/2004 Review, Vol. 23 Issue 43, p7233
Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways...
- Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish. Eckfeldt, Craig E.; Mendenhall, Eric M.; Flynn, Catherine M.; Tzu-Fei Wang; Pickart, Michael A.; Grindle, Suzanne M.; Ekker, Stephen C.; Verfaillie, Catherine M. // PLoS Biology;Aug2005, Vol. 3 Issue 8, p1449
Although several reports have characterized the hematopoietic stem cell (HSC) transcriptome, the roles of HSC-specific genes in hematopoiesis remain elusive. To identify candidate regulators of HSC fate decisions, we compared the transcriptome of human umbilical cord blood and bone marrow...
- Histocompatibility and Hematopoietic Transplantation in the Zebrafish. de Jong, Jill L. O.; Zon, Leonard I. // Advances in Hematology;2012, p1
The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly...
- Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Luis, T C; Ichii, M; Brugman, M H; Kincade, P; Staal, F J T // Leukemia (08876924);Mar2012, Vol. 26 Issue 3, p414
A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers and fate decisions made by progenitors derived from HSC must also be carefully regulated...
- Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation. Chambers, Stuart M.; Shaw, Chad A.; Gatza, Catherine; Fisk, C. Joseph; Donehower, Lawrence A.; Goodell, Margaret A. // PLoS Biology;Aug2007, Vol. 5 Issue 8, p1750
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression...
- ES-Cell Derived Hematopoietic Cells Induce Transplantation Tolerance. Bonde, Sabrina; Kun-Ming Chan; Zavazava, Nicholas // PLoS ONE;2008, Vol. 3 Issue 9, p1
Background: Bone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance. However, their strong immunogenicity precludes routine use in clinical transplantation due to the need for harsh preconditioning and the...
- Expression Profiling of Major Histocompatibility and Natural Killer Complex Genes Reveals Candidates for Controlling Risk of Graft versus Host Disease. Novota, Peter; Zinöcker, Severin; Norden, Jean; Wang, Xiao Nong; Sviland, Lisbet; Opitz, Lennart; Salinas-Riester, Gabriela; Rolstad, Bent; Dickinson, Anne M.; Walter, Lutz; Dressel, Ralf // PLoS ONE;2011, Vol. 6 Issue 1, p1
Background: The major histocompatibility complex (MHC) is the most important genomic region that contributes to the risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation. Matching of MHC class I and II genes is essential for the success of transplantation....
- Prevention of type 1 diabetes by gene therapy. Tian, Chaorui; Bagley, Jessamyn; Cretin, Nathalie; Seth, Nilufer; Wucherpfennig, Kai W.; Lacomini, John // Journal of Clinical Investigation;Oct2004, Vol. 114 Issue 7, p969
The autoimmune disease type 1 diabetes in humans and NOD mice is determined by multiple genetic factors, among the strongest of which is the inheritance of diabetes-permissive MHC class II alleles associated with susceptibility to disease. Here we examined whether expression of MHC class II...
