TITLE

Prostaglandin-mediated loss of proteins during peritonitis in continuous ambulatory peritoneal dialysis

AUTHOR(S)
Steinhauer, Hjalmar B.; Schollmeyer, Peter
PUB. DATE
February 1986
SOURCE
Kidney International;Feb1986, Vol. 29 Issue 2, p584
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The loss of proteins into the dialysate and the peritoneal generation of the immunoreactive prostanoids PGE2, 6-keto-PGF1α PGF2α, and TXB2; were studied in 12 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) during 16 episodes of peritonitis and in inflammation-free periods. Protein permeability, defined as the ratio of dialysate/plasma protein (D/P), decreased with increasing molecular weight, independent of the condition of the peritoneum. With peritonitis a general rise of permeability was noticed for total protein (TP) and the individual proteins β2-microglobulin (βMG), albumin (Alb), immunoglobulin G (IgG), and α2-macroglobulin (αMG) (P < 0.001). Simultaneously, an increase of dialysate prostanoids occurred with predominance of the vasodilative acting prostaglandins PGI2, determined as its metabolite 6-keto-PGF1α, and PGE2 by factors of 8.4 and 9.7, respectively (P < 0.001), in comparison to peritonitis-free control. In the early phase of peritonitis (0 to 12 hr after the onset of therapy) the augumented peritoneal prostaglandin synthesis correlated positively with the increased permeability of TP (r ≧ 0.7446, P < 0.01) and the individual proteins βMG, Alb, IgG, and αMG (r ≧ 0.5970, P < 0.05), Inhibition of cyclo-oxigenase activity by local administration of indomethacin inhibited both the generation of 6-keto-PGF1α and PGE2 by 39 and 42%, respectively (P < 0.05), and the peritoneal loss of TP by 34% (P < 0.05). In the absence of peritonitis indomethacin only diminished the synthesis of PGE2 whereas the generation of the other prostanoids remained unchanged. No effect occurred on peritoneal protein loss. The present data suggest that vasoactive prostaglandins are involved in the pathophysiology of increased peritoneal protein tosses in the early phase of CAPD-associated peritonitis.
ACCESSION #
17695208

 

Related Articles

  • Effect of the peritoneal dialysis prescription on pentosidine in children. Bayazit, Aysun K.; Vogt, Beth A.; Dell, Katherine M.; Davis, Ira D.; Noyan, Aytul; Anarat, Ali; Avner, Ellis D.; Erhard, Penny; Weiss, Miriam F. // Pediatric Nephrology;Oct2003, Vol. 18 Issue 10, p1049 

    Enhanced formation of advanced glycation end products (AGEs) by peritoneal dialysate containing high dextrose concentrations has been implicated as a source of peritoneal membrane toxicity and loss of viability in patients treated with peritoneal dialysis (PD). The goal of this project was to...

  • Proteomic profiling and identification in peritoneal fluid of children treated by peritoneal dialysis. Renske Raaijmakers; Wendy Pluk; Cornelis H. Schröder; Jolein Gloerich; Elisabeth A.M. Cornelissen; Hans J.C.T. Wessels; Johannes L. Willems; Leo A.H. Monnens; Lambert P.W.J. van den Heuvel // Nephrology Dialysis Transplantation;Jul2008, Vol. 23 Issue 7, p2402 

    Background. Proteomic technologies offer a high-throughput analysis of the expression of proteins in biological samples. The global analysis of the proteins in peritoneal dialysis (PD) fluid will provide a better understanding of the biological processes of the peritoneal membrane. Methods. The...

  • Serum prealbumin is higher in peritoneal dialysis than in hemodialysis: A meta-analysis. Goldwasser, Philip; Feldman, Joseph G.; Barth, Robert H. // Kidney International;Jul2002, Vol. 62 Issue 1, p276 

    Serum prealbumin is higher in peritoneal dialysis than in hemodialysis: A meta-analysis. Background. Although not widely appreciated, the reported concentration of serum preabumin, like that of serum cholesterol, tends to be higher in patients on peritoneal dialysis (PD) than on hemodialysis...

  • Protein losses during peritoneal dialysis. Blumenkrantz, Michael J.; Gahl, Gerhard M.; Kopple, Joel D.; Kamdar, Anjana V.; Jones, Michael R.; Kessel, Michael; Coburn, Jack W. // Kidney International;Apr1981, Vol. 19 Issue 4, p593 

    The losses of protein into dialysate have been considered a major limitation of maintenance peritoneal dialysis. We, therefore, undertook a comprehensive evaluation of protein losses in 30 patients undergoing maintenance intermittent peritoneal dialysis (IPD), 12 patients undergoing acute IPD,...

  • Serum albumin in continuous peritoneal dialysis: Its predictors and relationship to urea clearance. Malhotra, Deepak; Tzamaloukas, Antonios H.; Murata, Glen H.; Fox, Lucy; Goldman, Richard S.; Avasthi, Pratap S. // Kidney International;Jul1996, Vol. 50 Issue 1, p243 

    We investigated the predictors of serum albumin and the relationship between serum albumin and urea kinetic indices in continuous peritoneal dialysis (CPD), In a training set (TS) of 143 urea kinetic studies performed in 92 CPD patients, stepwise logistic regression identified high/high-average...

  • Plasma exchange v peritoneal dialysis for removing Bence Jones protein. Russell, J.A.; Fitzharris, B.M.; Corringham, R.; Harcy, D.A.; Powles, R.L. // British Medical Journal;11/18/1978, Vol. 2 Issue 6149, p1397 

    Presents a case on the use of plasma exchange and peritoneal dialysis for the removal of Bence Jones protein (BJP). Influence of BJP concentrations on the rise of renal failure; Comparison of the amounts of BJP removed using the two methods; Measurement of blood proteins concentrations by...

  • Practical methods for assessing dialysis efficiency during peritoneal dialysis. Krediet, Raymond T.; Koomen, Ger C.M.; Struijk, Dirk G.; Van Olden, Rudolf W.; Imholz, Alexander L.T.; Boeschoten, Elisabeth W. // Kidney International Supplement;Dec1994, Issue 48, pS-7 

    Focuses on the practical methods for assessing dialysis efficiency during peritoneal analysis. Protein equivalent of nitrogen appearance and rate of urea appearance; Role of serum proteins.

  • Aspiration of free blood from the peritoneal cavity does not mandate immediate laparotomy. Nagy, Kimberly K.; Fildes, John J. // American Surgeon;Sep1995, Vol. 61 Issue 9, p790 

    Presents a prospective study undergoing diagnostic peritoneal lavage (DPL). Relationship between the aspiration of free blood from the peritoneal cavity and DPL; Need to abandon aspiration as part of the DPL procedure in patients with abdominal trauma.

  • Exciting times for peritoneal dialysis. D'Souza, Paula // Journal of Renal Nursing;2012, Vol. 4 Issue 6, p270 

    An introduction is presented in which the editor discusses various articles within the issue on topics including the importance of pre-dialysis education for nurses, the use of assisted automated peritoneal dialysis (aAPD) and the biocompatible solutions in treatment of kidney disease.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics