TITLE

Tubulopathy in nephrolithiasis: Consequence rather than cause

AUTHOR(S)
Jaeger, Philippe; Portmann, Luc; Ginalski, Jean-Marie; Jacquet, Anne-Françoise; Temler, Evelyne; Burckhardt, Peter
PUB. DATE
February 1986
SOURCE
Kidney International;Feb1986, Vol. 29 Issue 2, p563
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To address whether a renal tubular dysfunction is encountered in a particular patient subgroup with urolithiasis, the following parameters of tubular function were measured in urine taken in the morning from 214 stone formers after fasting: pH, excretion of lysozyme and γ-glutamyl transferase (γ-GT); fractional excretion (FE) of glucose, insulin, Mg, K, and HCO3 after an alkali loading; and the renal threshold for phosphate (TmP/GFR). The following diagnoses were made in the patient group: primary hyperparathyroidism (N = 8), medullary sponge kidneys (N = 21), hyperuricemia (N = 10), cystinuria (N = 2), struvite stone disease [N = 6), idiopathic hypercalciuria of the absorptive (N = 25). dietary (N = 69) or renal (N = 7) type, and normocalciuric idiopathic urolithiasis (N = 66). In 31% of the patients TmP/GFR was below 0.80 mmole/liter and in 13% of the patients, FE HCO3 after alkali loading was above normal. Urinary excretion of lysozyme and that of γ-GT both were elevated in 17% of the patients. FE glucose, FE insulin, FE Mg, and FE K were elevated in 8, 9, 3, and 7% of the patients, respectively. This study demonstrates that a significant number of stone formers present with signs of renal tubular dysfunction, primarily involving the proximal tubule since apparent leaks of phosphate and of bicarbonate were most frequently encountered. The defects were not specific for a given etiologic group of patients; on the other hand, occurrence was related to the presence of large stones in the pyelocaliceal system at the time data were gathered. Taken together these data suggest that the tubulopathy in nephrolithiasis is the consequence rather than the cause of the stone.
ACCESSION #
17694608

 

Related Articles

  • Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture. Verkoelen, Carl F.; Van Der Boom, Burt G.; Kok, Dirk J.; Houtsmuller, Adriaan B.; Visser, Pim; Schröder, Fritz H.; Romijn, Johannes C. // Kidney International;Apr1999, Vol. 55 Issue 4, p1426 

    Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture. Background. Adherence of crystals to the surface of renal tubule epithelial cells is considered an important step in the development of nephrolithiasis. Previously, we demonstrated that functional...

  • Dissociation of gluconeogenesis from fluid and phosphate reabsorption in isolated rabbit proximal tubules. Yanagawa, Norimoto; Nagami, Glenn T.; Jo, Ok; Uemasu, Jiro; Kurokawa, Kiyoshi // Kidney International;Jun1984, Vol. 25 Issue 6, p869 

    Gluconeogenesis in the kidney is a metabolic function characteristic of proximal tubules. Recent studies suggest that renal gluconeogenesis (GNG) may in some way be coupled to fluid and phosphate reabsorption in the proximal tubule. Therefore, the present studies examined more directly the...

  • Interactions between D-glucose and phosphate in renal proximal tubule cells. Brazy, Peter C.; Chobanian, Michael C. // Kidney International Supplement;Dec1996, Issue 57, pS-30 

    The addition of D-glucose to renal proximal tubule cells reduces phosphate transport and in conditions of limited phosphate availability reduces mitochondrial respiration, oxidative phosphorylation and ATP content, a phenomenon called the Crabtree effect. The present study examined the effects...

  • Nephrocalcinosis in animal models with and without stones. Khan, Saeed // Urological Research;Dec2010, Vol. 38 Issue 6, p429 

    Nephrocalcinosis is the deposition of calcium salts in renal parenchyma and can be intratubular or interstitial. Animal model studies indicate that intratubular nephrocalcinosis is a result of increased urinary supersaturation. Urinary supersaturation with respect to calcium oxalate (CaOx) and...

  • Composition and morphology of phosphate stones and their relation with etiology. Daudon, Michel; Bouzidi, Hassan; Bazin, Dominique // Urological Research;Dec2010, Vol. 38 Issue 6, p459 

    Calcium phosphate (CaP) stones account for about 15% of all urinary stones, with a marked female preponderance, and reflect a wide diversity of etiology. Variation of the relative prevalence of CaP urolithiasis over time is disputed, and relevance of CaP stone analysis for etiologic diagnosis is...

  • Incomplete distal renal tubular acidosis affects growth in children. Ajay P. Sharma; Raj K. Sharma; Rakesh Kapoor; Alik Kornecki; Saubhik Sural; Guido Filler // Nephrology Dialysis Transplantation;Oct2007, Vol. 22 Issue 10, p2879 

    Background. Incomplete distal renal tubular acidosis (idRTA) is recognized as an underlying aetiology in recurrent nephrolithiasis. Until the recently reported high prevalence of idRTA in adults with osteoporosis, the effect of idRTA on skeletal parameters was not known. We hypothesize that...

  • Milkman's syndrome.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1471 

    A definition of the term "Milkman's syndrome," which refers to the failure of reabsorption of phosphate by the renal tubules, is presented.

  • Mechanisms through which high glucose concentration raises [Ca2+]i in renal proximal tubular cells. Symonian, Margarita; Smogorzewski, Miroslaw; Marcinkowski, Wojciech; Krol, Ewa; Massry, Shaul G // Kidney International;Oct1998, Vol. 54 Issue 4, p1206 

    Mechanisms through which high glucose concentration raises [Ca 2+ ]i in renal proximal tubular cells. Background. The basal levels of cytosolic calcium ([Ca2+ ]i) of renal proximal tubular cells of rats with streptozotocin-induced diabetes are elevated. It is possible that this phenomenon is...

  • Localization of the calcium-regulated citrate transport process in proximal tubule cells. Hering-Smith, Kathleen; Mao, Weibo; Schiro, Faith; Coleman-Barnett, Joycelynn; Pajor, Ana; Hamm, L. // Urolithiasis;Jun2014, Vol. 42 Issue 3, p209 

    Urinary citrate is an important inhibitor of calcium-stone formation. Most of the citrate reabsorption in the proximal tubule is thought to occur via a dicarboxylate transporter NaDC1 located in the apical membrane. OK cells, an established opossum kidney proximal tubule cell line, transport...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics