TITLE

Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease

AUTHOR(S)
Okuda, Seiya; Oh, Yukinori; Tsuruda, Hiroshi; Onoyama, Kaoru; Fujimi, Satoru; Fujishima, Masatoshi
PUB. DATE
February 1986
SOURCE
Kidney International;Feb1986, Vol. 29 Issue 2, p502
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Serial changes in urine protein, blood chemistry, and histology of the kidney were investigated in rats for 28 weeks after injections of adriamycin (ADR). Massive proteinuria, hypoalbuminemia, and hyperlipidemia were observed at week 4 and throughout the experiment. Both BUN and serum creatinine began to increase at week 16 and reached the uremic level at week 28. Light microscopic study of the kidney demonstrated a normal appearance at week 4, vacuole formation in glomerular tuft at weeks 8 and 12, focal and segmental glomerular sclerosis at weeks 16 and 20, and extensive glomerular sclerosis with tubulointerstitial degenerations at weeks 24 and 28. Immunohistologically, IgM with a small amount of IgG and C3 appeared in the sclerosing glomeruli from week 16. Aggregated human IgG, injected intravenously at week 24, had accumulated mainly in the glomeruli. Electron microscopy revealed degenerative changes of glomerular epithelial cells with small vacuoles in the cytoplasm at week 4. Size of vacuoles increased at the later stage. In conclusion, ADR produced chronic, progressive glomerular changes in rats, which led to terminal renal failure. The segmental glomerular sclerosis and IgM-dominant glomerular deposition in these animals are similar to pathological characteristics of focal and segmental glomerular sclerosis seen clinically.
ACCESSION #
17693983

 

Related Articles

  • Glomerular sieving of anionic and neutral bovine albumins in proteinuric rats. Bertolatus, John A.; Hunsicker, Lawrence G. // Kidney International;Sep1985, Vol. 28 Issue 3, p467 

    To characterize the effect in glomerular permeability leading to albuminuria in rats made nephrotic acutely by infusion of hexadimethrine (HDM) or chronically by administration of Adriamycin® (doxorubicin) (Adria), we developed and validated a tissue accumulation method for simultaneous...

  • Proteinuria. Barratt, Martin // British Medical Journal (Clinical Research Edition);11/19/1983, Vol. 287 Issue 6404, p1489 

    Examines the presence of proteinuria in renal diseases. Distinction between normal and pathological proteinuria; Measurement of the index of glomerular permeability; Difference of proteinuria in renal tubular disease and glomerular disease.

  • Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation. Zhang, Xueming; Qu, Xinli; Sun, Yu Bo Yang; Caruana, Georgina; Bertram, John F.; Nikolic-Paterson, David J.; Li, Jinhua // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Resolvin D1 (RvD1) is a lipid-derived mediator generated during the resolution inflammation. While the immunoresolvent effects of Resolvins have been extensively studied in leukocytes, actions of Resolvins on intrinsic kidney cells have received little attention. The podocyte plays a central...

  • Reversing glomerular hypertension stabilizes established glomerular injury. Meyer, Timothy W.; Anderson, Sharon; Rennke, Helmut G.; Brenner, Barry M. // Kidney International;Mar1987, Vol. 31 Issue 3, p752 

    Munich-Wistar rats were studied 18 weeks following 5⁄6 renal ablation. In untreated group 1 rats maintained on standard chow containing 24% protein, sustained systemic and glomerular hypertension were associated with increasing proteinuria and widespread glomerular injury. In group 2,...

  • Influence of converting enzyme inhibition on glomerular filtration rate and proteinuria. Rodicio, Josi L.; Alacazar, José M.; Ruilope, Luis M. // Kidney International;Oct1990, Vol. 38 Issue 4, p590 

    The article focuses on the influence of converting enzyme inhibition on glomerular filtration rate and proteinuria. The progression of chronic renal failure is facilitated by the presence of arterial hypertension. Proteinuria is a factor that indicates a poor prognosis for the progression of...

  • Elevated urinary excretion of the C5b-9 complex in membranous nephropathy. Schulze, Matthias; Donadio Jr., James V.; Pruchno, Charles J.; Baker, Patricia J.; Johnson, Richard J.; Stahl, Role A. K.; Watkins, Sandra; Martin, Donald C.; Wurzner, Reinhard; Gotze, Otto; Couser, William G. // Kidney International;Sep1991, Vol. 40 Issue 3, p533 

    ln experimental membranous nephropathy, antibody binding to glomerular epithelial cell membrane antigens results in complement activation and formation of complement C5b-9 membrane attack complexes in glomeruli. During active disease, the C5b-9 complexes are shed into hie urine. To test the...

  • Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases. Kerjaschki, Dontscho // Kidney International;Feb1994, Vol. 45 Issue 2, p300 

    Outlines a few examples of how some basic cell biological functions of podocytes can turn into focal points of glomerular disease. Podocyte shape-surface charge-proteinuria triangle; Cell membrane domains of podocytes; Adhesive properties of the basal cell membrane domain of podocytes; Slit...

  • Proteinuria--A direct cause of renal morbidity? Williams, John D.; Coles, Gerald A. // Kidney International;Feb1994, Vol. 45 Issue 2, p443 

    Examines the evidence in both humans and animals which purports to support the "proteinuria hypothesis." Mechanisms whereby increased glomerular permselectivity might contribute indirectly to a decline in renal function; Proteinuria as a predictor of renal disease; Reduced nephron mass; Overload...

  • Proteinuria and functional characteristics of the glomerular barrier in diabetic nephropathy. Carrie, Brian J.; Myers, Bryan D. // Kidney International;May1980, Vol. 17 Issue 5, p669 

    Fractional clearances of uncharged dextran 40 and anionic proteins were performed in an attempt to elucidate the defect in glomerular barrier function responsible for heavy proteinuria in diabetic nephropathy. Notwithstanding urinary albumin excretion (UalbV) at 3634 ± 608 µg/min, the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics