Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer

Logan, T. F.; Bensadoun, E. S.
July 2005
Thorax;Jul2005, Vol. 60 Issue 7, p610
Academic Journal
Sarcoidosis is a disease of unknown aetiology in which cytokines such as interleukin 2 (IL-2) are thought to play an important role. We present the case history of a 48 year old man with sarcoidosis who received treatment with high dose 11-2 for metastotic renal cell cancer, following which he developed hypercalcaemia characterised by a raised level of I ,25-dihydroxyvitamin D (1,25-(OH)2-D3), a finding consistent with sarcoidosis associated hypercalcaemia. The increased activity in his sarcoidosis following IL-2 treatment provides direct supportive evidence for the role of IL-2 in the pathogenesis of sarcoidosis.


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