TITLE

Severity of COPD is linked to decreased histone deacetylase activity

AUTHOR(S)
Nachman, S. A.
PUB. DATE
July 2005
SOURCE
Thorax;Jul2005, Vol. 60 Issue 7, p594
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on a research study on chronic obstructive pulmonary disease. Histone acetylation status depends on the equilibrium between the activities of histone acetyltransferase and histone deacetylase (HDAC). Acetylation prompts unwinding of histone and allows DNA transcription and production of cytokines. In this study the authors attempted to correlate changes in HDAC activity and expression with the severity of chronic obstructive pulmonary disease (COPD) as measured by spirometry. The authors conclude that patients with COPD have progressive reduction in total HDAC activity that reflects the severity of the disease.
ACCESSION #
17693113

 

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