Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy

Petersson, Christine; Hedges, Spencer; Stenqvist, Karin; Sandberg, Torsten; Connell, Hugh; Svanborg, Catharina
February 1994
Kidney International;Feb1994, Vol. 45 Issue 2, p571
Academic Journal
This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from nonpregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever. C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The lL-6 levels in serum and urine at diagnosis were significantly higher in the nonpregnant compared to the pregnant women. These results demonstrate that the immunosuppression of pregnancy includes the mucosal IL-6 and specific antibody responses to acute pyelonephritis caused by E. coli.


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