TITLE

A controlled trial of nandrolone decanoate in the treatment of uremic anemia

AUTHOR(S)
Cattran, Daniel C.; Fenton, Stanley S. A.; Wilson, Douglas R.; Oreopoulos, Dimitri; Shimizu, Arthur; Richardson, Robert M.
PUB. DATE
December 1977
SOURCE
Kidney International;Dec1977, Vol. 12 Issue 6, p430
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thirty-seven male dialysis patients, from three university hospital centers known to have adequate iron, B12, and folate stores, were entered into a controlled trial to study the effects of nandrolone decanoate (200 mg i.m. weekly) on their anemia. An initial six-month stabilization period was followed by a randomized 12-month study, with crossover between treatment and control groups occurring at six months. Patients received parenteral iron therapy plus oral folate throughout the trial. All serious illnesses or major blood losses excluded the patients from analysis. The 24 patients with remnant kidneys showed an increase in hemoglobin and hematocrit of 24% by the end of six months of treatment (P < 0.005), with a corresponding decrement during the six months of control, but the five anephric patients showed no statistically signficant change compared to those patients whose kidneys were in place during the study. Complications of treatment were minimal, with injection site hematoma the only significant local effect and a rise in triglyceride the only significant systemic disturbance. Despite the improvement in anemia, the disadvantages, including the high cost of treatment, the apparent plateauing of benefits by five months, the minimal subjective improvement in life style, the risk of i.m. injection, plus the long term effects of increased lipids, should limit this therapy to patients with remnant kidneys who have severe symptomatic anemia or frequent transfusion requirements.
ACCESSION #
17680925

 

Related Articles

  • Maintaining Higher TSATs and Other Iron Indices Is Beneficial in Management of Anemic Hemodialysis Patients. Dalton, Cheryl L. // Nephrology Nursing Journal;Aug2001, Vol. 28 Issue 4, p429 

    Presents information on the findings of a study on the efficacy of maintenance of transferrin saturation levels (TSATs) and other iron indices in the management of anemic hemodialysis patients. Limitations of iron indices and targets; Clinical evidence for benefits of higher TSATs; Conclusions.

  • Hct Levels <30% Carry High Risk of Mortality.  // Kidney;Sep/Oct99, Vol. 8 Issue 5, p208 

    Discusses an abstract of the article, entitled `Hematocrit level and associated mortality in hemodialysis patients,' by J.Z. Ma, J. Ebben, H. Xia and others.

  • Effectiveness of Treating the Renal Anemia in Chronic Hemodialyzed Patients by Epoietin Alpha and Beta. Ostrvica, Edin; Mesic, Enisa; Ostrvica, Dzenana; Delic, Jasmin; Delic-Custendil, Sunita; Hukic, Fatima // Medicinski Arhiv;2010, Vol. 64 Issue 1, p4 

    Introduction: Anemia is an early sign of chronic kidney dysfunction, caused by many different factors, but the insufficient erythropoietin synthesis is the crucial factor in its development. Objectives: The objective of our study was to compare effectiveness of epoietin alpha and beta...

  • Improved Anemia with EPO Associated with Significant Changes in BP.  // Kidney;Jan/Feb99, Vol. 8 Issue 1, p37 

    Details the findings of a study which investigated the variations in hemodynamic parameters, body fluid volumes and the hormones involved in blood pressure regulation in anemic hemodialysis (HD) patients before and after erythropoietin (EPO) therapy. Importance of reducing extracellular fluid...

  • Comparison of serum ferritin and transferrin saturation values associated with two i.v. iron formulations in hemodialysis patients. Nguyen, Timothy V. // American Journal of Health-System Pharmacy;6/15/2009, Vol. 66 Issue 12, p1101 

    Purpose. The effects of i.v. iron formulations on serum ferritin concentration (SFC) and transferrin saturation (TSAT) are compared in adult hemodialysis patients with anemia receiving erythropoiesisstimulating agents (ESAs). Methods. This study consisted of 215 patients who were receiving...

  • Clinical experience with darbepoietin alfa (NESP) in children undergoing hemodialysis. Giordano, Mario; Bellantuono, Rosa; Messina, Giovanni; Caringella, Angela D.; Palumbo, Fabrizio; Colella, Vincenzo; De Palo, Tommaso // Pediatric Nephrology;Mar2004, Vol. 19 Issue 3, p337 

    Darbepoietin alfa (NESP) is a new long-acting erythropoietin, with a half-life 3 times longer than the old epoietins. In the present study, we evaluated the efficacy of NESP in a group of children on hemodialysis. Seven children, five male and two female, with a mean age of 11.5±3 years and a...

  • Working Capacity Is Increased Following Recombinant Human Erythropoietin Treatment.  // JAMA: Journal of the American Medical Association;2/3/89, Vol. 261 Issue 5, p762 

    Investigates the effect on aerobic and anaerobic working capacity of partial correction of anemia in patients maintained on chronic intermittent hemodialysis. Bicycle spiroergometry; Recombinant human erythropoietin; Increase in oxygen uptake.

  • Vitamin C May Improve Anemia Care.  // Renal & Urology News;Jun2015, Vol. 14 Issue 5, p15 

    The article reports on the randomized study conducted by Romanian researchers regarding the benefits of ascorbic acid or vitamin C in managing hemodialysis (HD) patients with anemia.

  • Intravenous iron administration strategies and anemia management in hemodialysis patients. Michels, Wieneke M.; Jaar, Bernard G.; Ephraim, Patti L.; Yang Liu; Miskulin, Dana C.; Tangri, Navdeep; Crews, Deidra C.; Scialla, Julia J.; Shafi, Tariq; Sozio, Stephen M.; Bandeen-Roche, Karen; Cook, Courtney J.; Meyer, Klemens B.; Boulware, L. Ebony // Nephrology Dialysis Transplantation;Jan2017, Vol. 32 Issue 1, p173 

    Background. The effect of maintenance intravenous (IV) iron administration on subsequent achievement of anemia management goals and mortality among patients recently initiating hemodialysis is unclear. Methods. We performed an observational cohort study, in adult incident dialysis patients...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics