Renal handling of calcium in the early newborn period

Siegel, Sharon R.; Hadeed, Anthony
May 1987
Kidney International;May1987, Vol. 31 Issue 5, p1181
Academic Journal
Urinary calcium excretion was studied in two matched groups of 28 clinically-well preterm and fullterm infants between 24 and 48 hours of life. In the developmental period from 28 to 40 weeks gestation, urinary calcium excretion was positively correlated to the gestational age (r = 0.583, P < 0.01), serum calcium levels (r = 0.512, P < 0.01), the rate of glomerular filtration (r = 0.715, P < 0.001), and urinary cyclic AMP excretion (r = 0.717, P < 0.001). Urinary calcium excretion was independent of sodium and calcium intake, and urinary sodium and phosphate excretion. The mean fractional total calcium excretion and fractional ionized calcium excretion in babies ≤32 weeks was < 1.0%, compared to >2.5% for sodium. Serum calcium levels were positively correlated with gestational age (r = 0.803, P < 0.001), and serum phosphate levels (r = 0.85, P < 0.001). Whole blood ionized calcium levels were positively correlated to gestational age (r = 0.625. P < 0.001), and serum total calcium levels (r = 0.440, P < 0.05). The newborn kidney in babies ≤32 weeks gestation, did not have impaired conservation of calcium as for sodium: and neither sodium nor calcium intake appeared to affect urinary calcium excretion in the well newborn infant. Probably neither excess excretion of calcium nor serum phosphate levels contribute to early neonatal hypocalcemia.


Related Articles

  • Two- and three-dimensional CT measurements of urinary calculi length and width: a comparative study. Lidén, Mats; Thunberg, Per; Broxvall, Mathias; Geijer, Håkan // Acta Radiologica;Apr2015, Vol. 56 Issue 4, p487 

    The article focuses on a study which designs and validates a calculus oriented three-dimensional (3D) process to estimate the length and width of urinary calculi. The study also aims compare the calculus oriented measurements of the length and width with corresponding two-dimensional...

  • Postnatal management of infants with antenatally detected hydronephrosis. Aksu, Nejat; Yavaşcan, Őnder; Kangın, Murat; Kara, Orhan D.; Aydın, Yahya; Erdoğan, Hakan; Tuncel, Tuba Çerç; Çetinkaya, Ergün; Özbay, Erkan; Sandıkçıoğlu, Tahir G. // Pediatric Nephrology;Sep2005, Vol. 20 Issue 9, p1253 

    With the increasing use of antenatal sonography, fetal hydronephrosis has been reported more frequently. Because of the lack of consensus regarding treatment of these infants, the postnatal approach toward fetal renal pelvis enlargement remains controversial. The aim of this prospective study is...

  • Evaluation of urinary tract calculi in children. Hulton, S. -A. // Archives of Disease in Childhood;Apr2001, Vol. 84 Issue 4, p320 

    Renal stone disease remains a significant health problem in the adult population, with the incidence of urolithiasis estimated to be as high as 12 percent. The true incidence in childhood is not known, but a frequency of two children per million Great Britain population per annum has been...

  • Evaluación de factores de riesgo litogénico en neonatos sanos. Medina-Escobedo, Martha; Villanueva-Jorge, Salha; Salazar-Canul, Miguel; Medina-Escobedo, Carolina; Prado-Cuéllar, Alejandra // Bioquimia;jul2008, Vol. 33 Issue 3, p103 

    Introduction: Urolithiasis (UL) is endemic in Yucatán, Mexico; in infants with UL the hyperuricosuria is very frequent. Isolate observations suggests an increased in uricosuria of healthy newborns (HNB); by this is necessary to study the risk factors to urolithiasis in HNB from Yucatan....

  • Urolithiasis in infants. Mohamed, Jallouli; Riadh, Mhiri; Abdellatif, Nouri // Pediatric Surgery International;Apr2007, Vol. 23 Issue 4, p295 

    There are few publications about urolithiasis of the new born baby and infant (UNI). The UNI represents 20% of the pediatric urolithiasis. The etiologies in this age group are chiefly dominated by the urinary-tract infections and metabolic abnormalities. The purpose of this paper was to...

  • Ãœriner sistem taÅŸlarında iki senelik ÅŸok dalgası ile taÅŸ kırma tedavisi sonuçları. Davarcı, Mürsel; Rifaioğlu, Murat; Yalçınkaya, Fatih Rüştü; İnci, Mehmet // Dicle Medical Journal / Dicle Tip Dergisi;2012, Vol. 39 Issue 3, p377 

    Objectives: To evaluate the results of the extracorporeal electro shockwave lithotripsy (SWL) therapy in urinary system stone disease and to investigate the factors that affects the success. Materials and methods: Between February 2010 and December 2011, 101 patients, who had undergone SWL due...

  • Urinary calculi: improved detection and characterization with thin-slice multidetector CT. Ketelslegers, Etienne; van Beers, Bernard E. // European Radiology;Jan2006, Vol. 16 Issue 1, p161 

    The aim of this study was to assess the effect of reconstructed slice thickness on the detection and characterization of human urinary calculi on a multidetector helical CT scanner. Nineteen human urinary calculi of various chemical composition measuring 1.0-3.7 mm were embedded into agar in a...

  • Tretman komplicirane urolitijaze, etapno rjeÅ¡avanje. Junuzović, Dželaludin; Lepara, Zahid; Bajramović, Senad // Medical Archives / Medicinski Arhiv;2008, p60 

    Urolithiasis is very common disease. Among different urinal system problems, calculosis is on the third place. Bilateral calculosis takes about 10-25%. Huge stones which fill the pyelon have sprayed shape like sea coral (staghorn calculus), they are also known as coral shaped stones. It is...

  • Calcium Stone Growth in Urine from Cystic Fibrosis Patients and Healthy Controls. McSorley, Anita; Jones, Andrew M.; Webb, A. Kevin; Rao, P. Nagaraj; Kavanagh, John P. // AIP Conference Proceedings;2007, Vol. 900 Issue 1, p192 

    Cystic fibrosis patients have an increased risk of renal stone disease. There is some evidence that this may be related to a different excretory pattern of stone risk factors, but an alternative hypothesis, that the urine of cystic fibrosis patients is deficient in urinary inhibitors of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics